Special Issues

Special Issue Title: New Frontiers and Updates in the Diagnosis and Treatment of Female Infertility

· Print Special Issue Flyer

· Deadline for manuscript submissions: 31 December 2021

Special Issue Editor

Guest Editor

Dr. Amerigo Vitagliano

Gynecological Clinic, UOS Medically Assisted Procreation, University of Padova, via Nicolò Giustiniani 3, Padova, Italy

Website | E-Mail

Interests: infertility; assisted reproduction technologies; hysteroscopy; laparoscopy; reproductive biology; reproductive immunology; ovarian stimulation

Dr. Giovanni Buzzaccarini

Gynecological Clinic, UOS Medically Assisted Procreation, University of Padova, via Nicolò Giustiniani 3, Padova, Italy

Website | E-Mail

Interests: infertility; assisted reproduction technologies; pre-implantation genetic screening; ovarian stimulation

Dr. Andrea Busnelli

Department of Gynecology, Division of Gynecology and Reproductive Medicine, Fertility Center, Humanitas Clinical and Research Center - IRCCS, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy


Interests: infertility; fertility preservation; reproductive immunology; reproductive endocrinology

Special Issue Information

Dear Colleagues,

Infertility is a common problem that affects about 1 in 4 couples worldwide. Female infertility, defined as the inability to conceive naturally or to carry a pregnancy to full term, alone accounts for approximately one-third of all infertility cases. Female infertility can be due to different causes including the damage to fallopian tubes, reduced ovarian reserve, hormonal issues, advanced reproductive age, endometriosis, uterine malformations and defects in endometrial receptivity. Despite the great advances in diagnostics, pharmacology, minimally-invasive surgery and assisted reproduction technologies, female infertility still represent unsolved global health issues. There is urgent need to improve the global knowledge on female infertility as well as its clinical management.

In this Special Issue, we would like to move this field forward by inviting original clinical and basic research articles, meta-analyses and systematic reviews focusing on the diagnosis and management of female infertility.

We will be grateful to receive your submissions to move the field of female infertility forward.

Dr. Amerigo VitaglianoDr. Giovanni Buzzaccarini and Dr. Andrea Busnelli

Guest Editors


Manuscript Submission Information

Manuscripts should be submitted online at https://ceog.imrpress.org by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clinical and Experimental Obstetrics & Gynecology is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1250. Submitted papers should be well formatted and use good English.


Female infertility; Infertility diagnosis; Assisted reproductive technologies; Medical therapies; Novel strategies; Minimally-invasive surgery

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Fertility options in Mayer-Rokitansky-Küster-Hauser syndrome
Francesco Fedele, Alessandro Bulfoni, Stefano Salvatore, Massimo Candiani
Clinical and Experimental Obstetrics & Gynecology    2021, 48 (3): 453-460.   DOI: 10.31083/j.ceog.2021.03.2442
Abstract227)   HTML28)    PDF(pc) (738KB)(212)       Save

Background: The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the most common cause of uterine aplasia, with a worldwide frequency of 1 in 4500 females. Although abundant literature is present regarding the different available methods for creating a neovagina in MRKH syndrome, the attention dedicated to these women's reproductive potential remains insufficient. Methods: Online searches were carried out in PubMed database during November and December 2020. The search included a combination of the various terms (e.g., MRKH, vaginoplasty, uterus transplantation, infertility treatment, gestational surrogacy, etc.). The following inclusion criteria were used: (1) The articles should be written in English or French language. (2) The article should have been published by an official scientific organization. Results: Until few years ago, the only option for women with MRKH syndrome was legal adoption, now gestational surrogacy (GS) and uterine transplantation (UTx) have become new fertility options available to these patients. Discussion: GS is officially recognized in several countries and widely practiced. On the other hand, UTx, although the great recent technical improvements, is far from being an option for all women with MRKH syndrome secondary to its complexity and the necessary immunologic therapies.
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