Special Issues

Special Issue Title: Female infertility and treatment strategies

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·  Deadline for manuscript submissions: 31 May 2021



Special Issue Editor

Guest Editor


 Assist. Prof. Dr. Seda Karabulut

 Department of Histology and Embryology, School of Medicine, Istanbul Medipol University, Turkey

E-Mail1 | E-Mail2

Interests: Assisted reproduction techniques; In vitro fertilization (IVF); Infertility; Embryo culture; Fertility preservation; Cell signaling; Andrology


Special Issue Information

Dear Colleagues,


Infertility is defined as the inability of couples to have unprotected and regular sexual intercourse for at least 1 year (WHO, 2010) and around 15% of population face the issue with a fast increasing rate day by day. Female infertility contribute ~ 50 of all infertility cases. The main method to treat those couples is ‘assisted reproduction techniques’ which is based on collecting the oocytes and sperm cells, fusing them in a specialised laboratory, culturing embryos and transferring them back to mother’s uterus. Although the techniques are used to treat couples who can otherwise not conceive, current treatment strategies are capable of remedying only 40 % of them.

The medication, risks and procedure mostly affect the women, and the success rate is determined mostly by the female factors during all kinds of treatments including IUI, IVF and ICSI.

The goal of this special issue is to provide additional data for all aspects of female infertility and the treatment strategies.


Assist. Prof. Dr. Seda Karabulut 

Guest Editor

 

Manuscript Submission Information

Manuscripts should be submitted online at https://ceog.imrpress.org by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clinical and Experimental Obstetrics & Gynecology is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1250. Submitted papers should be well formatted and use good English.



Keywords

Assisted reproduction techniques; Female infertility; In vitro fertilization (IVF); Embryo culture; Fertility preservation


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Novel cellular entities and their role in the etiopathogenesis of female idiopathic infertility—a review article
Martin Klein, Lenka Lapides, Denisa Fecmanová, Ivan Varga
Clinical and Experimental Obstetrics & Gynecology    2021, 48 (3): 461-465.   DOI: 10.31083/j.ceog.2021.03.2395
Abstract185)   HTML20)    PDF(pc) (112KB)(111)       Save

Background: Idiopathic or unexplained infertility is a broad subcategory of infertility defined by the absence of obvious or explainable cause, but accounts for at least 25% of all causes. Many possible hidden factors have been discussed over the years, but one of the most prominent and controversial players in this area recently, have been telocytes—newly discovered interstitial cells. Telocytes were first described only 15 years ago, but as of today, they have been observed in almost all organs of the human body including the uterine tubes, uterus and other organs of the female reproductive system. Aside from their vast array of physiological functions such as immune regulation, cell-to-cell signalling, cell-nursing and hormone-sensing, they have been also implicated in the pathogenesis of many different diseases, for which we have coined an original term "telocytopathies". Methods: We have reviewed relevant articles in English on the topic of idiopathic infertility and telocytes mostly from the last 5 years, using PubMed/MEDLINE, Scopus and Web of Science databases. Results: Quantitative loss and functional derangement of telocytes many not cause any obvious pathological changes, but a subtle, yet important loss of crucial functions of telocytes can lead to unexplained infertility. Discussion: In the uterine tubes, possible mechanisms include changes in the structural and functional integrity of the cellular microenvironment. In the uterus, one of the main proposed mechanisms is immune dysregulation of macrophages and other immune cell populations. In the developing placenta, the main focus is placed on the role of telocytes in immune regulation and decidualisation. All these presupposed pathogenetic factors are still highly speculative, but possibly future research will elucidate the role of telocytes in these processes, which may lead to change of the status of idiopathic infertility, but also of many other "idiopathic" diseases regardless of the organ in question.
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