Special Issues

Special Issue Title: Inflammation during embryonic development - Studying the consequences of chorioamnionitis

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· Deadline for manuscript submissions:  1 October 2020  

Special Issue Editor

Guest Editor

    Prof. Nikolaos Papadopoulos

    University Hospital of Alexandroupolis, Medical School,

    Democritus University of Thrace, Dragana, Alexandroupolis, 68132, Evros Greece

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Interests: Fetal development; Chorioamnionitis; Consequences

Special Issue Information

Dear Colleagues,

    Inflammation during embryonic development from highly virulent organisms constitutes a serious complication of pregnancy with a high rate of fetal morbidity and mortality. This condition is due mostly from microoranisms such as, E. coli, group B streptococci and anaerobic bacteria that are normally present in the vagina. These pathogenic microorganisms ascend into the uterine cavity affecting at first the membranes that surround the fetus (chorion and amnion), a condition called acute chorioamnionitis. Clinically, the chorioamnionitis is characterized by maternal fever, leukocytosis, tachycardia, uterine tenderness and finally causing an inflammatory cascade that leads to preterm rupture of membranes / preterm birth.

    Evidence from humans and experimental models has been shown that chorioamnionitis is associated with a fetal inflammatory response which is characterized by increased release of systemic inflammatory cytokine and toxic molecules. It seems that these substances induce secondary growth disorders on fetal development which have been associated with the occurrence of serious complications and congenital malformations in various organs of the fetus. Disturbances that have been recorded in the development of the brain, sensory organs of sight and hearing, in the respiratory, gastrointestinal and urinary tract, and finally disorders of embryonic hematopoiesis in the liver, spleen and thymus gland.

Prof. Papadopoulos Nikolas

Guest Editor


Manuscript Submission Information

Manuscripts should be submitted online at https://ceog.imrpress.org by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clinical and Experimental Obstetrics & Gynecology is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1250. Submitted papers should be well formatted and use good English.


Fetal development; Chorioamnionitis; Consequences

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PCR positivity and D-dimer levels in pregnant women with COVID-19
K. Uzel, I. Lakhno
Clinical and Experimental Obstetrics & Gynecology    2020, 47 (5): 638-644.   DOI: 10.31083/j.ceog.2020.05.2229
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Background: Every day brings us new data on COVID-19, which has come to affect all the dynamics of the society, and increasingly more scientific literature becomes available on the topic. However, research information about its effects on particular groups, e.g., pregnant women, is still very limited. Aims: This study was aimed to investigate D-dimer levels in pregnant women admitted to the hospital with suspected COVID-19. Study Design: This descriptive cross-sectional study was carried out among pregnant women admitted to our hospital between 1 April 2020 and 31 May 2020 with suspected COVID-19. The data about patients was obtained from patient records and the hospital automation system. Methods: The primary outcome variable of the study was the D-dimer levels. Secondary outcome variables were the presence/absence of cough, shortness of breath, headache, fever, weakness, proteinuria, diarrhoea, haematuria, loss of taste, hypertension, and gestational diabetes mellitus. Results: Data for 64 pregnant women were analyzed. Thirty-three (51.5%) of them had a positive polymerase chain reaction (PCR) results, and thirty-one (48.5%) had negative ones. The mean age of the participants was 26.33 ± 5.15 years. Of the pregnant women, 51.6% (n = 33) were PCR (+) for COVID-19, and 48.5% (n = 31) were PCR (-). The mean age of the participants was 26.33 ± 5.15 years. Headache occurred significantly more often in PCR (+) pregnant women than in PCR (-) ones (χ2 = 4.201, p = 0.040). A statistically significant difference was found when the groups were compared in regard to the presence of the fever symptom (χ2 = 5.036, p = 0.025). When PCR (+) and PCR (-) pregnant women were compared, a statistically significant difference was found in the D-dimer levels (Z = 2.896, p = 0.004). A logistic regression model with PCR positivity as the dependent variables and headache, fever, and D-dimer levels as independent ones revealed a Nagelkerke R2 of 26.8%, and relatively high sensitivity (87.9%) and specificity (59.1%) values in predicting PCR positivity. Conclusion: This research is the first study to have suggested a model for predicting PCR positivity in women suspected of having the COVID-19 disease, which can speed up decision-making in regard to pregnant women with COVID-19.
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