Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (2): 263-269    DOI: 10.31083/j.ceog.2021.02.2408
Original Research Previous articles | Next articles
Comparison of immediate versus delayed frozen embryo transfer on reproductive outcome
Arzu Yurci1, *(), Aret Kamar2, Nurettin Turktekin2, Ramazan Ozyurt2
1Memorial Kayseri Hospital, IVF-Center, 38010 Kayseri, Turkey
2Istanbul In Vitro Fertilization Center, 34363 Istanbul, Turkey
Download:  PDF(523KB)  ( 148 ) Full text   ( 11 )
Export:  BibTeX | EndNote (RIS)      
Abstract  
The aim of this study was to compare impact of immediate versus delayed frozen frozen embryo transfer on reproductive outcome in patients undergoing IVF treatment. A total of 1478 infertile women with frozen embryos, aged between 18–42 years, were included the study. Patients were divided into two groups according to the time of embryo transfer. All transfers done in the first cycle after egg retrieval were deemed "immediate frozen ET" and a transfer done in any subsequent cycle was deemed "delayed frozen ET". The effects of immediate versus delayed FET on beta-hCG positivity, clinical pregnancy rate (CPR), ongoing pregnancy rate (OPR), live birth rate (LBR) and miscarriage rate were compared. Multiple logistic regression analysis was performed to exclude possible factors affecting reproductive parameters. Beta-hCG positivity, the number of patients with gestational sac and clinical pregnancy rates were found to be similar in both groups. The miscarriage rates in the Delayed FET group were found to be higher than the immediate FET group. Therefore, OPR was higher in the immeadiate FET group. When compared to the Delayed FET group, LBR was recorded as 1.3 times higher in the immediate FET group. When the cases with embryo transfer on the fifth or sixth day were compared with the cases with embryo transfer on the 3rd or 4th day, a 2.1 fold increase in LBR was found in the immediate FET group compared to the delayed FET group. Immediate FET done in the first cycle after egg retrieval increases the live birth rates while decreasing the abortion rates.
Key words:  Transfer time      Frozen embryo transfer      Reproductive outcome     
Submitted:  08 December 2020      Revised:  04 February 2021      Accepted:  24 February 2021      Published:  15 April 2021     
*Corresponding Author(s):  Arzu Yurci     E-mail:  arzuyurci@yahoo.com

Cite this article: 

Arzu Yurci, Aret Kamar, Nurettin Turktekin, Ramazan Ozyurt. Comparison of immediate versus delayed frozen embryo transfer on reproductive outcome. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 263-269.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.02.2408     OR     https://ceog.imrpress.com/EN/Y2021/V48/I2/263

[1] Zhongying Huang, Zhun Xiao, Qianhong Ma, Yu Bai, Feilang Li. Efficacy of tamoxifen for infertile women with thin endometrium undergoing frozen embryo transfer: a meta-analysis[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 806-811.
[2] Sh. Gaafar, T. Hanafy, S. El Morshedy, H. Mansour. Effect of extended embryo culture after thawing on clinical pregnancy rate[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 764-768.
[3] S. B. Cohen, M. Shapira, A. Baron, J. Bouaziz, R. Mashiach, M. Goldenberg, R. Orvieto. Ultrasonography-guided hysteroscopic tubal catheterization of proximally occluded tubes - reproductive outcomes[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 872-875.
[4] Jianping Zhang, Fang Yang, Yaoqin Wang, Yonglian Wang, Hongmei Liang, Xueqing Wu. Effect of differential endometrial injury timing on frozen-thawed embryo transfer pregnancy outcomes[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 118-122.
[5] Chunbo Yang, Binya Chen, Yonghong Tian, Yong Zhou, Junhua Shen, Hangmei Jin, Jun Lin. Rudimentary uterine horn pregnancy in 15 cases: case series with a two-year follow-up[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 702-706.
[6] J. H. Check, R. Cohen. A second successful pregnancy using oocytes from a woman with premature ovarian failure with embryos transferred to a gestational carrier[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 507-508.
[7] D. Summers, J. H. Check, J. K. Choe. A prospective comparison of outcome following cryopreservation using vitrification vs. a modified slow-freeze protocol of 2 pronuclear (2PN) and day 3 multi-cell embryos[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(3): 330-331.
[8] J.H. Check, J.K. Choe, R. Cohen, D. Corley, D. Horwath. The effect of conventional vs. mild ovarian hyperstimulation on the total number of live babies born from a given oocyte retrieval[J]. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(5): 571-572.
[9] S. Zhang, L. Gao, Y. Liu, J. Tan, Y. Wang, R. Zhang, Y. Liu, H. Chen, J. Zhang. Reproductive outcome and fetal karyotype of couples with recurrent miscarriages[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(3): 249-253.
[10] Xin Liu, Hua Duan, Yongjun Wang. Clinical characteristics and reproductive outcome following hysteroscopic adhesiolysis of patients with intrauterine adhesion - a retrospective study[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(2): 144-148.
[11] J.H. Check, D. Summers-Chase, W. Yuan, D. Horwath, M.C. Garberi-Levito. Pregnancy rates following the exclusive transfer of twice frozen twice thawed embryos using a modified slow cool cryopreservation technique[J]. Clinical and Experimental Obstetrics & Gynecology, 2013, 40(1): 20-21.
[12] J. Check, E. Dix, D. Check, D. Summers-Chase, D. Horwath. Pregnancy rates following frozen embryo transfer (ET) in women failing to conceive despite fresh ET in women using low dosage follicle stimulating hormone (FSH) protocol for follicular maturation of several eggs[J]. Clinical and Experimental Obstetrics & Gynecology, 2012, 39(2): 139-140.
[13] J.H. Check, B. Katsoff, C. Wilson, J.K. Choe, D. Brasile. Pregnancy outcome following fresh vs frozen embryo transfer into gestational carriers using a simplified slow freeze protocol[J]. Clinical and Experimental Obstetrics & Gynecology, 2012, 39(1): 23-24.
[14] J. H. Check, J. K. Choe, J. Amui, D. Brasile, T. Jamison. Evaluation of the importance of late follicular phaseendometrial echo patterns and pregnancy outcome followingembryo transfer by evaluating infertile donor/recipient pairs[J]. Clinical and Experimental Obstetrics & Gynecology, 2011, 38(4): 318-319.
[15] J. H. Check, R. Cohen, J. Amui, J. K. Choe, D. Brasile. Evidence that the main adverse effect of ganirelix on pregnancy and implantation rates is on the embryo rather than the endometrium[J]. Clinical and Experimental Obstetrics & Gynecology, 2011, 38(4): 326-327.
No Suggested Reading articles found!