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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (1): 128-131    DOI: 10.31083/j.ceog.2021.01.2209
Original Research Previous articles | Next articles
Is visual inspection with acetic acid (VIA) a useful method of finding pre-invasive cervical cancer?
Maliheh Arab1, *(), Atefeh Moridi2, Ghazaleh Fazli3, Robabeh Ghodssi-Ghasemabadi4, Maryam Maktabi5, Samaneh Saraeian6, Mahdie Sanati7
1Gynecology-Oncology, Cancer Research Center, Shahid Beheshti University of Medical Sciences, 1983963113 Tehran, Iran
2Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, 1983963113 Tehran, Iran
3Department of Developmental Biology, Science and Research University of Tehran, 1417466191 Tehran, Iran
4Department of Biostatistics, Tarbiat Modares University, 14117-13116 Tehran, Iran
5Obstetrics & Gynecology, Arak University of Medical Sciences, 38156879 Arak, Iran
6Obstetrician & Gynecologist, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, 1983963113 Tehran, Iran
7Developmental biology, Science and Research University of Tehran, 1417466191 Tehran, Iran
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Abstract  
Purpose of investigation: The prospects for effective cytological screening in the majority of developing countries are limited. This study evaluated visual inspection with acetic acid (VIA) for the diagnosis of CIN 2-3 in case findings. Materials and Methods: In this prospective study, 1437 asymptomatic women were screened using VIA followed by colposcopy-biopsy of all cases. The predictive efficacy of VIA was determined based on pathological confirmation of CIN 2-3 on colposcopy-directed biopsy. Results: In 388 (27%) out of 1437 cases, the VIA was positive. In 31 (2.1%) cases, CIN 2-3 was confirmed on cervical biopsy. The sensitivity, specificity and negative predictive value (NPV) of the VIA were 41.9%, 73.3%, and 98.2%, respectively. Conclusion: The present study confirmed the value of VIA for screening, with sensitivity of 41.9% and NPV of 98.2%. Future studies should determine the best place for VIA testing alongside other types of testing in screening algorithms.
Key words:  Screening      Cervical cancer      Cervical dysplasia      Colposcopy      Visual inspection with acetic acid      Iran     
Submitted:  04 July 2020      Revised:  15 October 2020      Accepted:  16 November 2020      Published:  15 February 2021     
*Corresponding Author(s):  Maliheh Arab     E-mail:  drmarab@sbmu.ac.ir

Cite this article: 

Maliheh Arab, Atefeh Moridi, Ghazaleh Fazli, Robabeh Ghodssi-Ghasemabadi, Maryam Maktabi, Samaneh Saraeian, Mahdie Sanati. Is visual inspection with acetic acid (VIA) a useful method of finding pre-invasive cervical cancer?. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 128-131.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.01.2209     OR     https://ceog.imrpress.com/EN/Y2021/V48/I1/128

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