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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (2): 219-226    DOI: 10.12891/ceog4485.2019
Original Research Previous articles | Next articles
Estrogen replacement therapy is not a recommended therapy for postmenopausal women with coronary heart disease: a meta-analysis
Y. Zheng1, G. Niu2, *(), H. Zhang1, W. Lu3, Z. Liu1
1Department of Drug Branch, Liaocheng People's Hospital, Liaocheng, Shandong, China
2Department of Endocrinology, Liaocheng People's Hospital, Liaocheng, Shandong, China
3Department of Obstetrics and Gynecology, Liaocheng People's Hospital, Liaocheng, Shandong, China
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Abstract  

Aim: This study was to investigate the effect of estrogen replacement therapy (ERT) on clinical outcomes for postmenopausal women with established coronary heart disease (CHD). Materials and Methods: The authors conducted a meta-analysis using 12 eligible studies. The overall odds ratios (OR) or standardized mean difference (SMD) and their corresponding 95% confidence interval (CI) were calculated. Results: For the incidence of adverse events, significant difference was observed in the occurrence rates of CHD death (OR = 1.166, 95% CI: 1.000-1.360, p = 0.050) and death of any cause (OR = 1.221, 95% CI: 1.057-1.410, p = 0.007) in postmenopausal women with CHD between ERT and placebo groups, whereas there was no significant difference (p > 0.05) in the occurrence rates of CHD events, myocardial infarction (MI), revascularization, unstable angina (UA), venous thromboembolic event, stroke/transient ischemic attack, and congestive heart failure between two groups. With respect to the alterations of other clinical outcomes, the SMD for the alteration of TC level was -0.192 (95% CI: -0.346—0.047, p = 0.015), and a significant difference was detected between the two groups, whereas there was no significant difference (p > 0.05) in the alterations of MLD and TG in patients between the two groups. Additionally, patients treated with ERT had lower LDL and higher HDL levels. Conclusion: This meta-analysis suggests that postmenopausal women with CHD receiving ERT are more likely to suffer from CHD death, death of any cause, lower LDL, and higher HDL and TC levels. Therefore, ERT should not be recommended to postmenopausal women with CHD for the secondary prevention of cardiovascular disease (CVD) clinically.

Key words:  Estrogen replacement therapy      postmenopausal women with CHD      clinic outcomes      meta-analysis     
Published:  10 April 2019     
*Corresponding Author(s):  G. NIU     E-mail:  niuguifen_sd@163.com

Cite this article: 

Y. Zheng, G. Niu, H. Zhang, W. Lu, Z. Liu. Estrogen replacement therapy is not a recommended therapy for postmenopausal women with coronary heart disease: a meta-analysis. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 219-226.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4485.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I2/219

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