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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (2): 335-336    DOI: 10.12891/ceog4706.2019
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Long standing post-herpetic neuralgia resistant to standard anti-neuropathy medication showing quick dramatic improvement following treatment with sympathomimetic amines
J.H. Check1, 2, *(), M.P. Dougherty3, D.L. Check2
1Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA;
2Cooper Institute for Reproductive and Hormonal Disorders, P.C., Mt. Laurel, NJ, USA
3The Commonwealth Medical College, Scranton, PA, USA
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Abstract  

Purpose: To determine if treatment with dextroamphetamine sulfate can alleviate severe chronic post-herpetic neuralgia that failed to respond to standard drugs typically used for neuropathy. Materials and Methods: An 88-year-old man with a five-year history of severe post-herpetic neuralgia pain who had failed to respond to pregabalin, and duloxetine was offered 15 mg of amphetamine salts extended release capsules. Eventually he was increased to 30 mg extended release capsules. Results: Within the first month of treatment there was significant relief of his pain with just 15 mg extended release capsule. After two months the dosage was increased to 30 mg extended release capsules and he has had at least a 90% reduction in pain which has lasted now five years. Discussion: Not only had this patient failed to respond to standard therapies for neuropathies, but he gained only marginal relief from lidocane patches, hydrocodone, oxydodone (all of which caused nausea), acupuncture, and TENS units. He has had no adverse side effects from the dextroamphetamine sulfate. Though the exact mechanism of action is not known for sure, the main hypothesis for the etiology of the sympathetic neural hyperalgesia syndrome is that the sympathetic nervous system controls cellular permeability, and a sensitive tissue already showing signs of increased permeability allows chemicals and toxic elements to permeate these tissues resulting in inflammation. The permeability problem is further compromised by sympathetic hypofunction. Dextroamphetamine sulfate is thought to stimulate the neurotransmitter dopamine which corrects the problem.

Key words:  Post-herpetic neuralgia      Amphetamines      Dextroamphetamine sulfate     
Published:  10 April 2019     
*Corresponding Author(s):  J.H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J.H. Check, M.P. Dougherty, D.L. Check. Long standing post-herpetic neuralgia resistant to standard anti-neuropathy medication showing quick dramatic improvement following treatment with sympathomimetic amines. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 335-336.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4706.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I2/335

[1] J.H. Check, D. Check, R. Cohen. A novel effective treatment for menière’s disease – dextroamphetamine sulfate[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 807-809.
[2] J.H. Check, D. Check. The increased cellular permeability syndrome manifesting as severe idiopathic type urinary incontinence[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 812-814.
[3] J.H. Check, R. Cohen. Sympathomimetic amine therapy abrogates severe long-term unexpalined abdominal pain and diarrhea (microscopic colitis) - possible infertility implications[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(3): 489-491.
[4] J.H. Check, D.L. Check, M.P. Dougherty. Marked improvement of the aromatase induced arthralgia syndrome following treatment with dextroamphetamine sulfate[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 291-292.
[5] J.H. Check, M. Citerone, T. Citerone. The increased cellular permeability syndrome as a cause of traumatic stuttering[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 773-774.
[6] J.H. Check. Changing the name of a syndrome: sympathetic neural hyperalgesia edema syndrome becomes – the increased cellular permeability syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 819-823.
[7] J.H. Check, R. Cohen. Amelioration of severe generalized idiopathic pruritus in an estrogen deficient woman taking an aromatase inhibitor for breast cancer following treatment with amphetamine salts[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 934-935.
[8] J. H. Check, R. Cohen. Marked improvement of severe gastroparesis following high dosage, but very well tolerated, dextroamphetamine sulfate[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 611-612.
[9] J.H. Check, A. Jaffe. Dextroamphetamine sulfate provided quick relief of severe post-partum depression that was recalcitrant to standard antidepressants and psychotherapy[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(2): 272-274.
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