Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (2): 291-292    DOI: 10.12891/ceog4707.2019
Case Report Previous articles | Next articles
Marked improvement of the aromatase induced arthralgia syndrome following treatment with dextroamphetamine sulfate
J.H. Check1, 2, *(), D.L. Check2, M.P. Dougherty3
1Cooper Medical School Of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA;
2Cooper Institute For Reproductive Hormonal Disorders, P.C. Marlton, NJ, USA
3The Commonwealth Medical College, Scranton, PA, USA
Download:  PDF(151KB)  ( 35 ) Full text   ( 4 )
Export:  BibTeX | EndNote (RIS)      
Abstract  

Purpose: To evaluate a novel treatment for aromatase induced arteralgia (AIA) syndrome. Materials and Methods: A woman already treated with dextroamphetamine sulfate for many years for a form of fibromyalgia developed AIA after 15 months of taking letrozole following mastectomy for breast cancer. Though she had already been taking dextroamphetamine sulfate 30mg extended release capsules for 25 years for other issues, her dosage was increased to 45mg. Results: Within a short length of time, the AIA manifesting as severe bilateral shoulder pain markedly improved. Conclusions: About 20% of women stop aromatase inhibitor therapy before the ideal 5 year time period because of bone pain and arthralgia. Sympathomimetic therapy should be considered. Hopefully this case will stimulate a larger prospective series. Content: Increasing the dosage of dextroamphetamine sulfate improved the pain from aromatase-induced arthralgia manifesting with severe bilateral shoulder pain.

Key words:  Aromatase inhibitor      arthralgia      dextroamphetamine sulfate      letrozole      sympathetic nervous system     
Published:  10 April 2019     
*Corresponding Author(s):  J.H. CHECK     E-mail:  laurie@ccivf.com

Cite this article: 

J.H. Check, D.L. Check, M.P. Dougherty. Marked improvement of the aromatase induced arthralgia syndrome following treatment with dextroamphetamine sulfate. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 291-292.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4707.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I2/291

[1] J.H. Check, D. Check, R. Cohen. A novel effective treatment for menière’s disease – dextroamphetamine sulfate[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 807-809.
[2] J.H. Check, D. Check. The increased cellular permeability syndrome manifesting as severe idiopathic type urinary incontinence[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 812-814.
[3] J.H. Check, R. Cohen. Sympathomimetic amine therapy abrogates severe long-term unexpalined abdominal pain and diarrhea (microscopic colitis) - possible infertility implications[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(3): 489-491.
[4] J.H. Check, M.P. Dougherty, D.L. Check. Long standing post-herpetic neuralgia resistant to standard anti-neuropathy medication showing quick dramatic improvement following treatment with sympathomimetic amines[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 335-336.
[5] J.H. Check, M. Citerone, T. Citerone. The increased cellular permeability syndrome as a cause of traumatic stuttering[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 773-774.
[6] J.H. Check. Changing the name of a syndrome: sympathetic neural hyperalgesia edema syndrome becomes – the increased cellular permeability syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 819-823.
[7] J.H. Check, R. Cohen. Amelioration of severe generalized idiopathic pruritus in an estrogen deficient woman taking an aromatase inhibitor for breast cancer following treatment with amphetamine salts[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 934-935.
[8] J. H. Check, R. Cohen. Marked improvement of severe gastroparesis following high dosage, but very well tolerated, dextroamphetamine sulfate[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 611-612.
[9] J.H. Check, J.R. Liss, D. Check. Influence of the conclusion of a recent large cooperative study in changing standard protocol of inducing menses in anovulatory women with oligomenorrhea prior to initiating ovulation induction with anti-estrogens and outcome[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(2): 180-182.
[10] J.H. Check, A. Jaffe. Dextroamphetamine sulfate provided quick relief of severe post-partum depression that was recalcitrant to standard antidepressants and psychotherapy[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(2): 272-274.
No Suggested Reading articles found!