|
|
|
A systematic review and meta-analysis of the reported symptoms of Covid 19 in pregnancy |
H.S.O. Abduljabbar1, *( ), H. Abduljabar2 |
1Department of Obstetrics &Gynecology, Medical College, King Abdulaziz University, P.O. Box 80215 Jeddah 21452, Kingdom of Saudi Arabia 2Department of Obstetrics &Gynecology, and Head of IVF Unit at King Faisal Specialties Hospital, Jeddah, Kingdom of Saudi Arabia |
|
|
Abstract Introduction: The percentage of Symptomatic pregnant and non-pregnant women infected with Covid 19 is the same. The common symptoms in pregnant women are cough, fever, sore throat and myalgia. The objective of this is systematic review and meta-analysis of the commonly reported symptoms of COVID 19 in pregnancy and to compare it to non-pregnant. Methods: Study Design; Systematic review and meta-analysis of published retrospective studies. Searches conducted from December 2019 - April 2020 on PubMed. Medline, EMBASE, ISI Web of Science Electronic database used to collect data, corresponding to the (PRISMA) Preferred Reporting Items for Systematic Meta-Analysis, using the following search terms: keywords "coronavirus, COVID-19, pregnancy". Results: Figure 1 presents the study flow diagram. We identify 114 records through database searching, sixteen further studies recognized through other sources, and 98 papers isolated after duplicates, leaving 32 reports. After screening for titles and abstracts, we found only 27 reports to be potentially suitable and rescued these reports in full text. We excluded seven studies; 20 did not report symptoms of groups of interest. In the process of Screening, 16 were screened. Ten of full-text articles assessed for appropriateness, six full-text articles omitted with reasons, and only Four studies [12-15] were included in the review. Conclusion: The only symptoms that are more common in pregnant than non-pregnant are the sore throat. That concluded that when pregnant women start to have sore throat care should be taken to exclude COVID-19 infection.
|
Submitted: 15 July 2020
Accepted: 24 August 2020
Published: 15 October 2020
|
*Corresponding Author(s):
H.S.O. Abduljabbar
E-mail: profaj17@yahoo.com
|
[1] |
Zhao X.Y., Xu X. X., Yin H. S., Hu Q. M., Xiong T., Tang Y. Y., et al.: "Clinical characteristics of patients with 2019 coronavirus disease in a non-wuhan area of hubei province, China: a retrospective study." 2020, 20, 311.
|
[2] |
Lu D., Sang L., Du S., Li T., Chang Y., Yang X.A., et al.: "Asymptomatic COVID‐19 infection in late pregnancy indicated no vertical transmission." J. Med. Virol., 2020.
doi: 10.1002/jmv.26614
pmid: 33079384
|
[3] |
Rasmussen S.A., Smulian J. C., Lednicky J. A., Wen T. S., Jamieson D. J.: “Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know”. Am. J. Obstet. Gynecol., 2020, 222, 415-426.
doi: 10.1016/j.ajog.2020.02.017
pmid: 32105680
|
[4] |
Lomauro A., Aliverti A., Alberigo D., Persico N., Frykholm P., Briganti F., et al.: “The effect of pregnancy on respiratory function”. Clin. Respir. Physiol., 2018, 52, OA2149.
|
[5] |
Brosnihan K., Brosnihan K.B., Neves L.A.A., Anton L., Joyner J., Valdes G., et al.: “Enhanced expression of Ang-(1-7) during pregnancy”. Brazil. J. Med. Biol. Res., 2004, 37, 1255-1262.
doi: 10.1590/S0100-879X2004000800017
|
[6] |
Fang L., Karakiulakis G., Roth M.: “Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?”. Lancet Respir. Med., 2020, 8, 21.
doi: 10.1016/S2213-2600(19)30410-2
pmid: 31676283
|
[7] |
Ali S.A., Baloch M., Ahmed N., Ali A.A., Iqbal A.: “The outbreak of Coronavirus Disease 2019 (COVID-19)-An emerging global health threat”. J. Infect. Public Health, 2020, 13(4), 644-646.
doi: 10.1016/j.jiph.2020.02.033
pmid: 32199792
|
[8] |
Kakodkar P., Kaka N., Baig M.: “A comprehensive literature review on the clinical presentation and management of the pandemic Coronavirus Disease 2019 (COVID-19)”. Cureus., 2020, 12, e7560.
doi: 10.7759/cureus.7560
pmid: 32269893
|
[9] |
Neyeloff J.L., Fuchs S.C., Moreira L.B.: “Meta-analyses and forest plots using a microsoft excel spreadsheet: step-by-step guide focusing on descriptive data analysis”. BMC Res. Notes, 2012, 5, 52.
doi: 10.1186/1756-0500-5-52
pmid: 22264277
|
[10] |
Li T., Gong L., Hu L., Ji H., Jiang Z., Zhu L.: “Clinical characteristics of non-pneumonia COVID-19 infection adults in Shanghai, China”. Research Square, 2020.
pmid: 32908974
|
[11] |
Özcan H., Elkoca A.: “COVID-19 Infectıon and its effects on pregnancy”. Anadolu KliniğiTıpBilimleriDergisi, 2020, 43-50.
|
[12] |
Yan J., Guo J.J., Fan C.F., Juan J., Yu X.C., Li J.F.: “Coronavirus disease 2019 (COVID-19) in pregnant women: A report based on 116 cases”. Am. J. Obstet. Gynecol., 2020, 223, e1-e14.
|
[13] |
Breslin N., Baptiste C., Gyamfi-Bannerman C., Miller R., Martinez R., Bernstein K., et al.: “Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals”. Am. J. Obstet. Gynecol., 2020, 2, 100118.
|
[14] |
Liu D., Li L., Wu X., Zheng D.D., Wang J.Z., Yang L., et al.: “Pregnancy and perinatal outcomes of women with Coronavirus Disease (COVID-19) pneumonia: a preliminary analysis”. Am. J. Roentgenol., 2020, 215, 127-132.
doi: 10.2214/AJR.20.23072
|
[15] |
Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W., et al.: “Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records”. Lancet, 2020, 395, 809-815.
doi: 10.1016/S0140-6736(20)30360-3
pmid: 32151335
|
[16] |
Tian S., Hu N., Lou J., Chen K., Kang X., Xiang Z., et al.: “Characteristics of COVID-19 infection in Beijing. J. Infect., 2020, 80, 401-406.
doi: 10.1016/j.jinf.2020.02.018
pmid: 32112886
|
[17] |
Moher D., Liberati A, Tetzlaff J, Altman D.G.: “Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement”. PLoS Med., 2009, 6, e1000097.
doi: 10.1371/journal.pmed.1000097
pmid: 19621072
|
[18] |
Dashraath P., Wong J.L.J., Lim M.X.K., Lim M.L., Li S., Biswas A., ., et al.: “Coronavirus disease 2019 (COVID-19) pandemic and pregnancy”. Am. J. Obstet. Gynecol., 2020, 222, 521-531.
doi: 10.1016/j.ajog.2020.03.021
pmid: 32217113
|
[19] |
Hasan M.Z., Kibria G.M.A., Alam T.: “Pregnancy during the evolving pandemic Coronavirus Disease 2019 (COVID-19): A rapid scoping review of evidence in the published literature”. 2020. [Preprint]
|
[20] |
Panahi L., Amiri M., Pouy S.: “Clinical characteristics of COVID-19 infection in newborns and pediatrics: a systematic review.” Arch. Acad. Emerg. Med., 2020, 8, e50.
pmid: 32440661
|
[21] |
Gatta A.N.D., Rizzo R., Pilu G., Simonazzi G.: “Coronavirus disease 2019 during pregnancy: a systematic review of reported cases”. Am. J. Obstet. Gynecol., 2020, 223, 36-41.
doi: 10.1016/j.ajog.2020.04.013
pmid: 32311350
|
[22] |
Tu H.L., Tu S., Gao S.Q., Shao A., Sheng J.F.: "Current epidemiological and clinical features of COVID-19; a global perspective from China". J. Infect., 2020, 81, 1-9.
doi: 10.1016/j.jinf.2020.04.011
pmid: 32315723
|
[23] |
Lu D.W., Sang L., Du S.H., Li T., Chang Y.G., Yang X.A.: “Asymptomatic COVID‐19 infection in late pregnancy indicated no vertical transmission”. J. Med. Virol., 2020.
doi: 10.1002/jmv.26614
pmid: 33079384
|
[24] |
Karimi-Zarchi M., Neamatzadeh H., Dastgheib S.A., Abbasi H., Mirjalili S.R., Behforouz A., et al.: “Vertical transmission of Coronavirus Disease 19 (COVID-19) from infected pregnant mothers to neonates: a review”. Fetal. Pediatr. Pathol., 2020, 39, 246-250.
doi: 10.1080/15513815.2020.1747120
pmid: 32238084
|
[25] |
Mayor S.: “Covid-19: Nine in 10 pregnant women with infection, when admitted for delivery, are asymptomatic, small study finds”. BMJ, 2020, 369, m1485.
doi: 10.1136/bmj.m1485
pmid: 32291260
|
[26] |
Bauer M.E., Bernstein K., Dinges E., Delgado C., El-Sharawi N., Sultan P., et al.: “Obstetric anesthesia during the COVID-19 Pandemic”. Anesth. Analg., 2020, 131, 7-15.
pmid: 32265365
|
[27] |
Porfidia A., Pola R.: “Venous thromboembolism in COVID‐19 patients”. J. Thrombo. Haemosta., 2020, 18, 1516-1517.
doi: 10.1111/jth.v18.6
|
[28] |
Bampoe S., Odor P.M., Lucas D.N.: "Novel coronavirus SARS-CoV-2 and COVID-19. Practice recommendations for obstetric anaesthesia: what we have learned thus far." Int. J. Obstet. Anesth., 2020, 43, 1-8.
doi: 10.1016/j.ijoa.2020.04.006
pmid: 32437912
|
[1] |
Aaron Y. Kluger, Kristen M. Tecson, Clay M. Barbin, Andy Y. Lee, Edgar V. Lerma, Zachary P. Rosol, Janani Rangaswami, Norman E. Lepor, Michael E. Cobble, Peter A. McCullough. Cardiorenal Outcomes in the CANVAS, DECLARE-TIMI 58, and EMPA-REG OUTCOME Trials: A Systematic Review[J]. Reviews in Cardiovascular Medicine, 2018, 19(2): 41
-49
. |
[2] |
Kun Zhao, Hong Wan, Zhigang Shang, Xinyu Liu, Lu Liu. Intracortical microstimulation parameters modulate flight behavior in pigeon[J]. Journal of Integrative Neuroscience, 2019, 18(1): 23
-32
. |
[3] |
Rudaynah A. Alali. A short review of proprotein convertase subtilisin/kexin type 9 inhibitors[J]. Reviews in Cardiovascular Medicine, 2019, 20(1): 1
-8
. |
[4] |
Davide Bolignano, Giuseppe Coppolino. Renal nerve ablation for resistant hypertension: facts, fictions and future directions[J]. Reviews in Cardiovascular Medicine, 2019, 20(1): 9
-18
. |
[5] |
Jing Jin, Yufeng Liu, Lihong Huang, Hong Tan. Advances in epigenetic regulation of vascular aging[J]. Reviews in Cardiovascular Medicine, 2019, 20(1): 19
-25
. |
[6] |
Yun Tian, Pingji Deng, Bing Li, Jieqiong Wang, Ju Li, Yulan Huang, Yan Zheng. Treatment models of cardiac rehabilitation in patients with coronary heart disease and related factors affecting patient compliance[J]. Reviews in Cardiovascular Medicine, 2019, 20(1): 27
-33
. |
[7] |
Miklós Bitay, Sándor Varga, Barna Babik, Kálmán Havasi, Tamás Szücsborus. Infective Endocarditis complicated with Coronary Artery Septic Embolization: Is It Worth to Be Mentioned? Case Presentation and Review of the Literature[J]. Reviews in Cardiovascular Medicine, 2019, 20(1): 35
-39
. |
[8] |
Mingjun Tian, Minjuan Zheng, Hui Ma, Yicui Niu, Ying Zhang, Pan Xu. Differentiation of patients with two-dimensional echocardiography false positive non-compaction of ventricular myocardium by contrast echocardiography[J]. Reviews in Cardiovascular Medicine, 2019, 20(1): 41
-46
. |
[9] |
Feier Song, Huimin Zhan, Yuanfeng Liang, Xuyu He, Lan Guo. Cardiac rehabilitation improved oxygen uptake measured by cardiopulmonary exercise test in patients after aortic valve surgery[J]. Reviews in Cardiovascular Medicine, 2019, 20(1): 47
-52
. |
[10] |
Peter Shalit. Management of Dyslipidemia in Patients With Human Immunodeficiency Virus[J]. Reviews in Cardiovascular Medicine, 2014, 15(S1): 38
-46
. |
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|