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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (4): 565-570    DOI: 10.31083/j.ceog.2020.04.5243
Original Research Previous articles | Next articles
Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta
J.Y. Yan1, , *(), P.P. Chen2, L.L. Jiang1, , H.L. Zhang1, Q. Han1, R.X. Chen1, Q.J. Zhang1
1Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350001, P.R. China
2Second affiliated hospital of Fujian medical university, Quanzhou, Fujian, 362001, P.R. China
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Abstract  
Objective: This study aims to explore the role of hypoxia inducible factor-1α (HIF-1α) in morbidly adherent placenta (MAP). Materials and Methods: Ten pregnant women with placenta increta, 20 pregnant women with placenta previa, and 30 normal pregnant women as controls participated in the present study. Real-time reverse transcription polymerase chain reaction (RT-PCR) was used to measure the mRNA expression of HIF-1α in the placenta. Enzyme-linked immunosorbent assay (ELISA) was performed to analyze the HIF-1α protein levels in the placenta. Results: The mean expression of placental HIF-1α in the placenta increta and placenta previa groups was significantly higher than that in the normal placenta. The level of placental HIF-1α in the placenta increta was significantly higher than that in the placenta previa (p < 0.05). The level of placental HIF-1α had no obvious correlation with the accreta site and umbilical cord insertion. Conclusion: The morbidly of adherent placenta is closely correlated to adverse pregnancy outcomes during the perinatal period. Placental HIF-1α is associated with morbidly adherent placenta.
Key words:  HIF-1α      Placenta increta      Placenta previa      Pathogenesis      Morbidly adherent placenta     
Submitted:  21 April 2019      Accepted:  22 July 2019      Published:  15 August 2020     
Fund: 
[2015] No. 593/Key Clinical Specialty Discipline Construction Fujian, P.R.C.
2018Y0005/Fujian Science and Technology Leading Project
2017-CX-11/Fujian Medical Innovation Subject
*Corresponding Author(s):  JIANYING YAN     E-mail:  y_ying007@aliyun.com
About author:  Contributed equally.

Cite this article: 

J.Y. Yan, P.P. Chen, L.L. Jiang, H.L. Zhang, Q. Han, R.X. Chen, Q.J. Zhang. Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 565-570.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.04.5243     OR     https://ceog.imrpress.com/EN/Y2020/V47/I4/565

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