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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (3): 427-428    DOI: 10.31083/j.ceog.2020.03.4946
Case Report Previous articles | Next articles
Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome
D. Lu1, †, D. Cao2, †, Q. Zhao3, †, X. Chen2, *()
1Department of Clinical Laboratory, Women and Children's Hospital of Hubei Province, Wuhan, Hubei, P.R. China
2Department of Obstetrics; Women and Children's Hospital of Hubei Province, Wuhan, Hubei, P.R. China
3Department of Clinical Laboratory, Dongsheng Area People's Hospital, Ordos, Inner Mongolia, P.R. China
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Abstract  

We report a case of prenatal diagnosis of mosaicism for chromosome t (7; 14) with a favorable fetal outcome. Similar chromosomal abnormalities have been observed in patients with hematologic malignancy. Chromosomal microarray analysis (CMA) revealed no genomic imbalance, prenatal ultrasound examination revealed no intrauterine growth restriction (IUGR) or dysmorphisms in this fetus. Therefore, combination of karyotype analysis, CMA, genetic counseling and prenatal ultrasound will prove a more specific risk evaluation for chromosomal translocation and mosaicism.

Key words:  Karyotype analysis      CMA      Chromosome translocation      Mosaic      Hematologic malignancy      Prenatal diagnosis     
Submitted:  17 July 2018      Accepted:  04 February 2019      Published:  15 June 2020     
*Corresponding Author(s):  XIANGYI CHEN     E-mail:  bioxia@163.com
About author:  Contributed equally.

Cite this article: 

D. Lu, D. Cao, Q. Zhao, X. Chen. Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(3): 427-428.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.03.4946     OR     https://ceog.imrpress.com/EN/Y2020/V47/I3/427

Figure 1.  — The karyotype of 46,XY,t(7; 14)(q35; q13).

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