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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (1): 12-15    DOI: 10.31083/j.ceog.2020.01.4923
Original Research Previous articles | Next articles
Prenatal diagnosis of ductus venosus agenesis: a retrospective study of associated cytogenetic/congenital anomalies
M. Özsürmeli1, *(), M. Sucu1, E. Arslan1
1Department of Obstetrics and Gynecology, Perinatology Unit, School of Medicine, University of Çukurova, Adana, Turkey
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Abstract  

Introduction: Absence of the ductus venosus (ADV) is a rare vascular anomaly often associated with fetal cardiac/extracardiac anomalies, aneuploidies, and hydrops. This study assesses the abnormal venous circulation, associated malformations, and chromosomal anomalies of ADV. Materials and Methods: The authors performed a retrospective study of 14 cases with ADV diagnosed by the prenatal ultrasound in tertiary referral center from 2009 to 2017. Results: The authors detected 14 patients of ADV. Karyotyping was offered to all cases, and four patients accepted the procedure. Normal karyotype was found in three out of four cases, while one case had 45, X0. Five cases underwent termination of pregnancy, six cases died at neonatal period due to accompanying cardiac anomalies, and heart failure. Three cases survived (the oldest baby is 4-years-old now). Umbilical vein (UV) was connected to portal venous system (PVS) in two cases (intrahepatic drainage, one of them is surviving), while UV was connected to systemic venous circulation in 12 cases (extrahepatic drainage, two of them are surviving). In five cases there was no other reason that might explain cardiomegaly and hydrops except ADV (two of them is surviving). Three cases were diagnosed as cystic hygroma in first trimester additionally found ADV. All of surviving fetuses delivered after 35th weeks of gestation. Conclusion: The presence fetal hydrops, accompanying congenital anomalies, and prematurity are associated with poor prognosis in fetuses with ADV. In isolated cases, the prognosis is generally good.

Key words:  Prenatal diagnoses      Ductus venosus      Umbilical vein      Congenital abnormality     
Published:  15 February 2020     
*Corresponding Author(s):  M. Özsürmeli     E-mail:  ozsurmeli@gmail.com

Cite this article: 

M. Özsürmeli, M. Sucu, E. Arslan. Prenatal diagnosis of ductus venosus agenesis: a retrospective study of associated cytogenetic/congenital anomalies. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 12-15.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.01.4923     OR     https://ceog.imrpress.com/EN/Y2020/V47/I1/12

Table 1  — Associated anomalies, UV connection type, and outcomes in 14 cases with agenesis of the ductus venosus.
GA at diagnosis (weeks) GA at delivery (weeks) Associated anomalies UV
connection
Karyotype Outcomes
1 28 35 Cardiac: VSD, cardiomegaly, tricuspid insufficiency
Extra cardiac: agenesis of corpus callosum
RA Not performed NL
2 35 39 Ebstein anomaly, pulmonary stenosis PVS Not performed NL
3 24 24 Cardiac: AVSD
Extra cardiac: Dandy Walker anomaly, micrognathia

VCI

Not performed

TOP
4 30 30 Cardiomegaly, hydrops RA Not performed NL
5 35 35 Cardiomegaly RA Not performed 4 years of life, survivor
6 13 13 Cystic hygroma, hydrops RA Not performed TOP
7 30 39 Cardiac: cardiomegaly, VSD
Extra cardiac: ventriculomegaly, pelvic kidney
RA Not performed 3 years of life, survivor
8 13 13 Cystic hygroma RA Not performed TOP
9 12 12 Cystic hygroma, AVSD RA 45, X0 TOP
10 25 37 Cardiac: truncus arteriosus
Extra cardiac: cerebellum hypoplasia
RA Normal NL
11 22 22 Cardiac: heterotaxia
Extra cardiac: ventriculomegaly
VCI Normal TOP
12 34 34 Cardiomegaly, hydrops VCI Not performed NL
13 23 36 Cardiomegaly PVS Normal 8 months of life, survivor
14 32 32 Hydrops, cardiomegaly RA Not performed NL
Figure 1.  — Ultrasonographic imaging of ductus venosus agenesis.

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