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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (6): 992-998    DOI: 10.12891/ceog4877.2019
Case Report Previous articles | Next articles
Monophasic synovial sarcoma of the lower extremity at 20 weeks of pregnancy: a case report and review of the literature
P. Bielikova1, R. Pilka1, *(), K. Huml1, B. Melichar1, H. Svebisova2, J. Jankova3, V. Prasil4, I. Zambo5, P. Janicek6
1Department of Obstetrics and Gynaecology, St. Anne's University Hospital, Brno, Czech Republic
2Department of Oncology, St. Anne's University Hospital, Brno, Czech Republic
3Department of Molecular and Clinical Pathology, St. Anne's University Hospital, Brno, Czech Republic
4Department of Radiology, University Hospital, Olomouc, St. Anne's University Hospital, Brno, Czech Republic
5First Department of Pathological Anatomy, St. Anne's University Hospital, Brno, Czech Republic
6First Department of Orthopedic Surgery, Faculty of Medicine, Masaryk University, St. Anne's University Hospital, Brno, Czech Republic
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Abstract  

Introduction: The incidence of malignancy in pregnancy is reported to range approximately between 0.02% and 1%. Synovial sarcoma (SS) is a rare aggressive mesenchymal tumor for which there are no treatment guidelines during pregnancy. Case Report: The authors report a 23-year-old primigravida presenting, at 20+0 weeks of pregnancy, with a growing painful mass in the left thigh. The diagnosis of monophasic SS grade 3 was confirmed by the presence of SYT gene fusion. On MRI scan there was a heterogeneous localized mass of size 75×115×103 mm, but there was no evidence of distant metastases. Limb-sparing surgery with clear-surgical margins was performed at 26+3 weeks of pregnancy. Adjuvant chemotherapy with two cycles of doxorubicin was followed by delivery of normal child by caesarean section at 36+3 weeks of pregnancy. Adjuvant radiotherapy of total dose of 66 Gray to the site of the resection had been administered followed by two cycles of doxorubicin. Conclusion: The patient is free of recurrence six months after the completion of the treatment.

Key words:  Synovial sarcoma      Malignancy      Pregnancy      Limb-sparing surgery     
Published:  10 December 2019     
*Corresponding Author(s):  R. PILKA     E-mail:  radovan.pilka@fnol.cz

Cite this article: 

P. Bielikova, R. Pilka, K. Huml, B. Melichar, H. Svebisova, J. Jankova, V. Prasil, I. Zambo, P. Janicek. Monophasic synovial sarcoma of the lower extremity at 20 weeks of pregnancy: a case report and review of the literature. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 992-998.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4877.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I6/992

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