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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (6): 933-937    DOI: 10.12891/ceog4941.2019
Original Research Previous articles | Next articles
The effects of exogenous melatonin administration on bone in ovariectomized and pinealectomized rats
Ö. Murat1, 2, *(), Ç. Önder1, 2
1Obstetrics and Gynecology, Seyhan City Hospital, Adana, Seyhan, Turkey
2Obstetrics and Gynecology, Private Clinic, Usak, Turkey
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Abstract  

Introduction: One of the most common metabolic bone disease is postmenopausal osteoporosis. There is data that pineal melatonin (MLT) is decreased with age and that menopause is correlate with a substantial decrease in melatonin secretion and increased rate of pineal gland calcification. Because of this, in the present study, the authors aimed to assess pinealectomy-induced melatonin deficiency in menopause which may be a contributing factor in the development of postmenopausal osteoporosis. Materials and Methods: A total of 49 young Wistar-Albino rats were included in the study. Some groups underwent bilateral ovariectomy (OVX) via the dorsal route, and pinealectomy (PX) was performed with Kuszack and Rodin method. Following PX and OVX, selected groups were given a dose of 5 mg /kg/day injected intraperitoneally. The authors evaluated bone mineral density (BMD) of the femur by dual-energy X-ray absorptiometry. The BMD of femur named as proximal 1/3 (RI), middle 1/3 (R2), distal 1/3 (R3), and total (R4). Results: Compared with the sham group, PX + MLT group had significantly higher BMD values at R3 subregion. There is no statistically significant relationship between PX+OVX group and PX+OVX+MLT group at subregions. Compared with the OVX + MLT group, PX+OVX+MLT group had significantly higher BMD values at R1, R3, and R4 subregions. Conclusion: PX significantly increases BMD at R3 subregion, but its not reversed by exogenous MLT administration. OVX cancelled the effects of PX with respect to increases in the levels of reached bone mass. Exogenous MLT administration to OVX and PX group did not increase BMD values.

Key words:  Postmenopausal osteoporosis      Melatonin      BMD     
Published:  10 December 2019     
*Corresponding Author(s):  ÖZŞAHIN. MURAT     E-mail:  mozsahn@yahoo.com

Cite this article: 

Ö. Murat, Ç. Önder. The effects of exogenous melatonin administration on bone in ovariectomized and pinealectomized rats. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 933-937.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4941.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I6/933

[1] Çiğdem Kunt İşgüder, Murat Uysal, Özlem Koşar Can, Mine Kanat Pektaş, Akgül Arici, Velid Unsal. Protective effects of apocynin and melatonin on ovarian ischemia/reperfusion injury in rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 98-104.
[2] He Hu, Guowei Zhang, Geng Tian, Guang Lv, Yongli Jin. miRNA profiling reveals the upregulation of osteogenesis-associated miRNAs in ovariectomy osteoporosis mice[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(6): 817-822.
[3] E.S. Yılmaz, T. Sapmaz, H. Kazgan, S. Menziletoglu Yıldız, D. Kocamaz, N. Akpolat, E. Sapmaz. Examination of the effect of melatonin use before hysterosalpingography on ovarian follicle reserve in rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(4): 570-574.
[4] K. Bakay, H. Ulubaşoğlu, T. Atan, H. Alaçam, D. Güven, S. Batioğlu. The effect of physical activity on the levels of the hormones, serotonin and melatonin in premenstrual syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(3): 425-427.
[5] Bo Ma, Yuhu Li, Xiulan Zhang, Liuguang Zhang, Ning Li, Ping Yu. Supplementation of IVF solutions with melatonin improves assisted reproductive technology results[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 209-213.
[6] M. Zhang, Y. Li, Q. Ma, W. Mao, Y. Gao, Y. Liu, B. Liang. Relevance of parathyroid hormone (PTH), vitamin 25(OH)D3, calcitonin (CT), bone metabolic markers, and bone mass density (BMD) in 860 female cases[J]. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(2): 129-132.
[7] E. Sapmaz, A. Kale, N. Akpolat. Melatonin use in unilateral total salpingectomy in rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2012, 39(2): 186-190.
[8] A.Ç. Altungül, A. Kale, E. Sapmaz, N. Akpolat. Examination of the effect of melatonin use in Pomeroy method of tubal ligation on ovarian histology in rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2012, 39(1): 103-106.
[9] L. Tripodi, A. Tripodi, C. Mammi, C. Pulle, A. Pecile, F. Cremonesi. Pharmacological effects of melatonin on reproductive activity: experimental bioimplants with sustained-release polymeric systems[J]. Clinical and Experimental Obstetrics & Gynecology, 2004, 31(2): 117-119.
[10] L. M. Chiechi, T. Valerio, P. Loizzi. Postmenopausal osteoporosis and celiac disease[J]. Clinical and Experimental Obstetrics & Gynecology, 2002, 29(3): 185-186.
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