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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (4): 595-598    DOI: 10.12891/ceog3597.2017
Original Research Previous articles | Next articles
First trimester maternal serum marker in intrahepatic cholestasis of pregnancy
O. Temizkan1, *(), B. Aydogan1, B. Arıcı1, O. Aşıcıoğlu1, P. Yalcin1
1 Department of Gynecology and Obstetrics, Sisli Etfal Traning and Research Hospital, Istanbul, Turkey
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Abstract  Purpose of investigation: The authors investigated the difference between the first-trimester maternal serum markers of intrahepatic cholestasis of pregnancy (ICP) cases and uneventful pregnancies, which might be useful in disease prediction. Materials and Methods: Twenty patients who had ICP and 40 pregnant women as control group were enrolled and the first-trimester maternal serum markers, maternal and fetal outcomes were compared between two groups. First trimester maternal serum markers: pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (β-hCG) are the essential components of aneuploidy screening and prediction of adverse obstetric outcome. Results: Serum PAPP-A and free β-hCG levels were significantly higher in the ICP group. The mean serum PAPP-A was significantly higher in the ICP than control groups (2.4 ± 0.9 MoM vs. 1.2 ± 0.3 MoM: p < 0.001, respectively) and the mean of serum free β-hCG was significantly higher in the ICP than control groups (1.8 ± 1.5 MoM vs. 1.2 ± 0.6 MoM; p = 0.036, respectively). Gestational week at birth and the birth weights were lower in the ICP group (p < 0.001 and p = 0.005, respectively). Conclusion: The first-trimester maternal serum markers were elevated in case of ICP and this might be useful in disease prediction.
Key words:  Bile acids      Free β-hCG      Intrahepatic cholestasis of pregnancy      Pregnancy associated plasma protein A     
Published:  10 August 2017     
*Corresponding Author(s):  O. TEMIZKAN     E-mail:  mdtemizkan@yahoo.com

Cite this article: 

O. Temizkan, B. Aydogan, B. Arıcı, O. Aşıcıoğlu, P. Yalcin. First trimester maternal serum marker in intrahepatic cholestasis of pregnancy. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 595-598.

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https://ceog.imrpress.com/EN/10.12891/ceog3597.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I4/595

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