Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (3): 489-491    DOI: 10.12891/ceog3647.2017
Case Report Previous articles | Next articles
Should sexual intercourse be avoided during the embryo transfer cycle? Life-threatening ruptured heterotopic pregnancy after single thawed embryo transfer: case report and review of the literature
Y. Aoki1, *(), J. Kumakiri1, A. Itakura1, I. Kikuchi1, N. Takahashi1, T. Satoru1
1 Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan
Download:  PDF
Export:  BibTeX | EndNote (RIS)      
Abstract  Background: To report the life-threatening complication of a raptured heterotopic pregnancy occurring from thawed single embryo transfer. Case Report: A 33-year-old woman underwent in vitro fertilization (IVF) under a step-up regimen. After oocyte collection, blastocysts were frozen, and a single frozen-thawed blastocyst was then transferred according to the natural cycle. On day 17 after embryo transfer, an intrauterine pregnancy was confirmed. On day 28, she complained of sudden abdominal pain and ultrasonography revealed marked fluid retention in the peritoneal cavity. Emergency laparoscopy was performed, revealing hemoperitoneum and a ruptured interstitial heterotopic pregnancy (HP), which was then resected laparoscopically. Because sexual intercourse had occurred shortly before the transfer, a HP comprising a spontaneous pregnancy and a pregnancy achieved by assisted reproductive technology was assumed. The fetus in the uterus survived and was delivered. Conclusion: In this case, however, despite the single embryo transfer during the natural-cycle frozen-thawed embryo transfer process, the risk of life-threatening complication as a HP as a consequence of spontaneous pregnancy after sexual intercourse remained.
Key words:  Heterotopic pregnancy      Single embryo transfer      Laparoscopy      Interstitial pregnancy      Hemoperitoneum     
Published:  10 June 2017     
*Corresponding Author(s):  Y. AOKI     E-mail:  youichiaokijp@yahoo.co.jp

Cite this article: 

Y. Aoki, J. Kumakiri, A. Itakura, I. Kikuchi, N. Takahashi, T. Satoru. Should sexual intercourse be avoided during the embryo transfer cycle? Life-threatening ruptured heterotopic pregnancy after single thawed embryo transfer: case report and review of the literature. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(3): 489-491.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3647.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I3/489

[1] Ranit Hizkiyahu, Shannon Salvador, Michael H. Dahan. Ovarian stimulation for fertility preservation in a woman with borderline serous ovarian tumor causing a large fluctuating subcutaneous fluid collection: a case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1215-1218.
[2] Üzeyir Kalkan, Murat Yassa, Kadir Bakay, Şafak Hatırnaz. Mechanical bowel preparation prior to gynaecological laparoscopy enables better operative field visualization, lower pneumoperitoneum pressure and Trendelenburg angle during the surgery: a perspective that may add to patient safety[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 842-850.
[3] Basilio Pecorino, Giuseppe Scibilia, Placido Borzì, Maria Elena Vento, Pierfrancesco Veroux, Paolo Scollo. Diminished ovarian reserve and ectopic ovaries in patients with Mayer-Rokitansky-Küster-Hauser syndrome candidates for Uterus Transplantation: our experience[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 907-912.
[4] Li-Min Zhou, Jie Duan, Yan Yang. Endoscopic treatment with concomitant ultrasound monitoring of obstructive septum in Robert's uterus following pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 711-714.
[5] Su-Xian Zhang, Lu Wu, You-Fang Hou, Bo Yan, Shao-Yan Yang, Li-Hua Yang, Qing-Hua Zhao. Hemoperitoneum caused by bleeding of adenomyosis: a case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 444-447.
[6] L.B. Liu, H.T. Sun, S.F. Liu, R.X. Shi. Laparoscopy combined with hysteroscopy for cesarean scar pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 911-914.
[7] M.S. Kim, E.D. Na, H.C. Kim, M. Kim, S.Y. Shin, M.H. Lee. Torsion of a rudimentary uterine horn with multiple leiomyomas in a case of Mayer-Rokitansky-Küster-Hauser syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 968-971.
[8] C. Chan, J.W. Wang, C.W. Wang, C.W. Chang. A pitfall in ultrasonographic diagnosis–heterotopic cornual pregnancy initially misdiagnosed as leiomyoma[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 296-298.
[9] K. Sandal, I. Yetimoglu, M. A. Sargin, N. Tug. Ruptured myometrial tumors as a cause of spontaneous hemoperitoneum[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 303-305.
[10] A. Lavinia Cozlea, E. Előd Élthes, Á. Török, M. Emil Capîlna. Clinical presentation, risk factors and management of ectopic pregnancy: a case-control study[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 914-919.
[11] Y. Wang, F.Y. Luo, Y.D. Xia, L. Mei, L. Xie, H.X. Liu. Clinical analysis of 211 cases of cesarean scar pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 948-952.
[12] R. T. Ratner, A. Harris, J. Tsaltas, N. Goyal, M. Davies-Tuck, H. Najjar, O. Barel. An eight-year retrospective analysis of laparoscopic surgery for endometriosis, outcomes and complications in a large multicenter unit[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 699-703.
[13] X. Lu, Q. Tian, S. Zhou, S. Zhang, X. Sun, G. Tian. Acute hemoperitoneum in third trimester: two case reports[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 821-823.
[14] A. Pontis, L. Nappi, F. Sorrentino, S. Angioni. Differential diagnosis of adenomyosis: the role of hysteroscopy and laparoscopy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 511-515.
[15] M. Simonsen, L. Martins Campbell, R. Moretti Marques. Uterine manipulator - low budget option[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 575-577.
No Suggested Reading articles found!