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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (3): 453-457    DOI: 10.12891/ceog3235.2017
Experimental Research Previous articles | Next articles
Protective effect of curcumin on ovarian reserve in a rat ischemia model: an experimental study
A. Eser1, *(), D. Hizli1, M. Namuslu2, H. Haltas3, N. Kosus1, A. Kosus1, H. Kafali4
1 Turgut Ozal University Medical School Department of Obstetrics and Gynecology, Ankara, Turkey
2 Turgut Ozal University Medical School Department of Biochemistry, Ankara, Turkey
3 Turgut Ozal University Medical School Department of Pathology, Ankara, Turkey
4 Gazi University Medical School Department of Obstetrics and Gynecology, Ankara, Turkey
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Abstract  Purpose of investigation: To determine the protective effect of curcumin on ovarian reserve in a rat ischemia model. Materials and Methods: Thirty female Albino rats were randomly divided into two groups by time of unilateral, left ovary ischemia/reperfusion (group 1: two-hour ischemia/two-hour reperfusion; group 2: four-hour ischemia/four-hour reperfusion). Each group was subdivided into three subgroups, sham, control, and curcumin (intraperitoneal curcumin (200 mg/kg) simultaneously with reperfusion). Histological grading of ischemic indices of paraffin-embedded ovarian tissue using hematoxylin and eosin (H&E), and anti-Mullerian hormone (AMH) levels by enzyme-linked immunosorbent assay (ELISA), were measured 40 days later. Results: No difference was found between groups 1 and 2 or among subgroups within either group for right and left ovary grades. AMH levels were significantly higher in the curcumin subgroup compared to sham and control within group 2 and in group 2 versus group 1 curcumin subgroups. Conclusion: Curcumin maintains and protects ovarian functions in an ischemia-reperfusion rat model.
Key words:  Curcumin      Ovarian reserve      Rat-ischemia model      Ischemia-reperfusion      Anti-Müllerian hormone     
Published:  10 June 2017     
*Corresponding Author(s):  A. ESER     E-mail:  aylaacar76@yahoo.com.tr

Cite this article: 

A. Eser, D. Hizli, M. Namuslu, H. Haltas, N. Kosus, A. Kosus, H. Kafali. Protective effect of curcumin on ovarian reserve in a rat ischemia model: an experimental study. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(3): 453-457.

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https://ceog.imrpress.com/EN/10.12891/ceog3235.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I3/453

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