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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (1): 129-132    DOI: 10.12891/ceog3148.2017
Experimental Research Previous articles | Next articles
The effect of leflunomide on the transplanted endometriosis lesions in SD rats
J.J. Yang1, 2, Y. Gao2, Y.H. Wang2, C.H. Wang2, L.D. Wang1, *(), B.B. Tao2, H.F. Guo2, S.G. Ding2, A.H. Wu2, G.R. Zhai2, X.M. Feng2
1 The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2 Women and Infants Hospital of Zhengzhou, Zhengzhou, China
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Abstract  
Objective: To investigate the effects of the leflunomide (LEF) on the size of the transplanted endometriosis (EMS) lesions and transforming growth factor (TGF) -β1gray level in SD rats. Materials and Methods: EMS was surgically induced in rats by autologous transplantation and the focal volume was also measured. The rats were divided into three groups: group A: normal SD rats, group B: rats irrigated by one ml·kg-1·d-1 saline for three weeks, and group C: rats irrigated by 35 mg·kg-1·d-1 LEF for three weeks. The rats were then sacrificed and measured their focal volume and TGF-β1 gray value with immunohistochemical method. Results: The sizes of the focal volume in group C were significantly reduced compared to the rats before feeding, and the volume in group C was smaller than group B after feeding and so was the TGF-β1. Conclusion: LEF could be a new therapeutic drug for EMS.
Key words:  Ectopic endometriosis model in rats      Endometriosis      Leflunomide      TGF-β1     
Published:  10 February 2017     
*Corresponding Author(s):  L.D. WANG     E-mail:  yjj_168@126.com

Cite this article: 

J.J. Yang, Y. Gao, Y.H. Wang, C.H. Wang, L.D. Wang, B.B. Tao, H.F. Guo, S.G. Ding, A.H. Wu, G.R. Zhai, X.M. Feng. The effect of leflunomide on the transplanted endometriosis lesions in SD rats. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(1): 129-132.

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https://ceog.imrpress.com/EN/10.12891/ceog3148.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I1/129

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