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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (1): 65-69    DOI: 10.12891/ceog3217.2017
Original Research Previous articles | Next articles
Hysterosalpingography prior to the gonadotropin stimulated intrauterine insemination improves clinical pregnancy rates in women with unexplained infertility
E. Caglayan1, E. Okyay1, T. Bodur1, *(), C. Ertugrul1, E. Koyun1, M. Kovali1, E. Dogan1, B. Gulekli1
1 Dokuz Eylul University, Obstetrics & Gynecology Department, Izmir, Turkey
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Abstract  
Purpose of investigation: Gonadotropin stimulated intrauterine insemination (IUI) cycles performed following one month after hysterosalpingography (HSG) are associated with improvement in clinical pregnancy rates in unexplained infertile couples. Materials and Methods: A retrospective cohort study was performed between 2008 and 2014. A total of 92 unexplained infertile couples undergoing their first cycle IUI stimulated by gonadotropins were included in the analysis. Participants were classified into two groups according to IUI cycles performed one month (Group A, n = 25 cycles) or longer than one month (Group B, n = 67 cycles) after the HSG procedure. Result: The overall clinical pregnancy rate was found as 25% (23 clinical pregnancies / 92 cycles). Clinical pregnancy rate was 44 % (11/25) for Group A and 17.9 % (12/67) for Group B. In Group A, there were significantly higher clinical pregnancy rates compared to Group B (OR: 3.6, 95% CI, 1.3–9.8; p = 0.012). Conclusions: It has been demonstrated that fertility improving effect of HSG was most prominent in the first six months after procedure. Likewise, in gonadotropin stimulated IUI cycles performed following one month after HSG, there seems to be an improvement in pregnancy rates in unexplained couples. In unexplained cases, it may be a reasonable approach to plan IUI cycles in the first month after HSG in clinical practice.
Key words:  Ovarian stimulation      Infertility      Hysterosalpingography     
Published:  10 February 2017     
*Corresponding Author(s):  T. BODUR     E-mail:  taylanbodur@hotmail.com

Cite this article: 

E. Caglayan, E. Okyay, T. Bodur, C. Ertugrul, E. Koyun, M. Kovali, E. Dogan, B. Gulekli. Hysterosalpingography prior to the gonadotropin stimulated intrauterine insemination improves clinical pregnancy rates in women with unexplained infertility. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(1): 65-69.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3217.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I1/65

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