Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 757-762    DOI: 10.12891/ceog4774.2019
Original Research Previous articles | Next articles
Long non-coding RNA steroid receptor activator in polycystic ovary syndrome: possible association with metabolic syndrome
H.M.G. Youssef1, *(), E.S. Marei1, L.A. Rashed2
1Health Radiation Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt
2Faculty of Medicine, Cairo University, Cairo, Egypt
Download:  PDF(643KB)  ( 212 ) Full text   ( 11 )
Export:  BibTeX | EndNote (RIS)      
Abstract  

Introduction: Polycystic ovary syndrome (PCOS) is a metabolic and endocrine disorder which affects women of reproductive age with a prevalence of 8-18% and implies various severe consequences to female health, including alarming rates of infertility, which accounts for approximately 75% of anovulatory infertility. Long non-coding RNA steroid receptor activator (lncRNA-SRA) affects multiple biological processes. However, it is not known whether lncRNA-SRA is associated with PCOS and the possible accompanied metabolic syndrome (MetS). Material and Methods: The expression levels of lncRNA-SRA were measured by real-time quantitative-PCR in PCOS patients (n=30 women), and in control group (n=20 women), patients with metabolic syndrome were diagnosed, and the association between lncRNA-SRA and metabolic syndrome parameters in PCOS group and control were analyzed. Results: LncRNA-SRA expression mean level was significantly higher in the women with PCOS than that in the control group. There was a high significant positive correlation between lncRNA-SRA expression and hirsutism, BMI, waist circumference (WC), and insulin levels, also with significant positive correlation between lncRNA-SRA with HOMA/IR and testosterone in PCOS group. Conclusion: The authors found that the lncRNA-SRA expression is potentially increased with PCOS and it has positive correlation with hirsutism, obesity, testosterone, and insulin resistance in PCOS. LncRNA-SRA is significantly increased in MetS subgroup of PCOS, thereby suggesting that elevated lncRNA-SRA might be an important mediator not only associated to hormonal and clinical parameters but also associates metabolic syndrome in PCOS and may be a mediator in the pathogenesis of both syndromes.

Key words:  LncRNA-SRA      Polycystic ovary syndrome      Metabolic syndrome      Insulin resistance      Hirsutism     
Published:  10 October 2019     
*Corresponding Author(s):  H.M.G. YOUSSEF     E-mail:  hanangabr62@gmail.com

Cite this article: 

H.M.G. Youssef, E.S. Marei, L.A. Rashed. Long non-coding RNA steroid receptor activator in polycystic ovary syndrome: possible association with metabolic syndrome. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 757-762.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4774.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I5/757

[1] J. Dun, X. Wang, J. Yang, J. Xu. Clinical practice guidelines on polycystic ovary syndrome: a systematic review and comparative meta-analysis[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 465-471.
[2] Xiao-Tao Huang, Shao-Rong Liang, Lu Wang. Acupuncture combined with Chinese and western medicine in the treatment of polycystic ovary syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(3): 396-400.
[3] F. N. Tuysuzoglu, G. A. Ilhan, B. Yildizhan. The impact of surgical menopause on metabolic syndrome, bone mineral density, and vasomotor symptoms[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 179-182.
[4] A. M. Maysara, A. T. Nassar, H. K. Jubran. The effect of correction of serum level of vitamin D on hyperandrogenism in women with polycystic ovary syndrome and hypovitaminosis D[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 272-276.
[5] M. Trisovic, O. Mladenovic, J. Bila, K. Lalić, D. Kisic Tepavcevic. The predictive value of metabolic syndrome in the evaluation of pregnancy course and outcome[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 776-778.
[6] M.H. Vieira de Melo, M.T. Albuquerque Barbosa Cabral Micussi, R. Dias de Medeiros, R. Ney Cobucci, T.M. de Oliveira Maranhão, A.K. Gonçalves. Pelvic floor muscle thickness in women with polycystic ovary syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(6): 813-816.
[7] Jung Yeob Seoung, Suk Woo Lee, Young Mo Kang, Min Jung Kim, Jae Min Park, Hye Min Moon, Chae Chun Rhim. Association between metabolic risks and bone mineral density in postmenopausal women[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 671-676.
[8] H. Bagci, R. Melekoglu, M.F. Gursu, A. Akyol, F. G. Bulmus. Associations between serum levels of adiponectin and resistin and metabolic parameters in pregnant women with gestational diabetes mellitus[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(4): 539-543.
[9] Hui-lan Wang, Xia Xu, Zhi-qun Zheng. The expression of Nuclear Factor-κB in a rat model of polycystic ovary syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 276-279.
[10] Y.J. Lee, K.Y. Yun, S.C. Kim, J.K. Joo, K.S. Lee. The association between cystatin C and metabolic syndrome according to menopausal status in healthy Korean women[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(5): 716-720.
[1] Eli M. Roth, Michael H. Davidson. PCSK9 Inhibitors: Mechanism of Action, Efficacy, and Safety[J]. Reviews in Cardiovascular Medicine, 2018, 19(S1): 31 -46 .
[2] Sandeep K. Krishnan, Norman E. Lepor. Acute and Chronic Cardiovascular Effects of Hyperkalemia: New Insights Into Prevention and Clinical Management[J]. Reviews in Cardiovascular Medicine, 2016, 17(S1): 9 -21 .
[3] Ibrahim Sidiqi, Patrick Alexander. Current Advances in Endovascular Therapy for Infrapopliteal Artery Disease[J]. Reviews in Cardiovascular Medicine, 2015, 16(1): 36 -50 .
[4] Peter Shalit. Management of Dyslipidemia in Patients With Human Immunodeficiency Virus[J]. Reviews in Cardiovascular Medicine, 2014, 15(S1): 38 -46 .
[5] Sophie Mavrogeni, Fabrizio Cantini, Gerald M. Pohost. Systemic Vasculitis: An Underestimated Cause of Heart Failure—Assessment by Cardiovascular Magnetic Resonance[J]. Reviews in Cardiovascular Medicine, 2013, 14(1): 49 -55 .
[6] George L. Smith. Appropriate Use Criteria: The Gold Standard, or a Mechanism for the Derogation of Clinical Judgment?[J]. Reviews in Cardiovascular Medicine, 2011, 12(2): 105 .
[7] Prabhjot Singh Nijjar, Anoop Parameswaran, Aman M. Amanullah. Evaluation of Anomalous Aortic Origins of the Coronaries by 64-Slice Cardiac Computed Tomography[J]. Reviews in Cardiovascular Medicine, 2007, 8(3): 175 -181 .
[8] . SELF-ASSESSMENT POST-TEST[J]. Reviews in Cardiovascular Medicine, 2006, 7(S2): 51 -52 .
[9] Alice K. Jacobs. Gender Differences in Coronary Revascularization: Does Age Make a Difference?[J]. Reviews in Cardiovascular Medicine, 2004, 5(1): 68 -70 .
[10] Jeffrey W. Moses, Stephane Carlier, Issam Moussa. Lesion Preparation Prior to Stenting[J]. Reviews in Cardiovascular Medicine, 2004, 5(S2): 16 -21 .