Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 727-730    DOI: 10.12891/ceog4741.2019
Original Research Previous articles | Next articles
Luteal phase progesterone and estradiol concentrations and their relation to the outcome of IVF/ICSI cycles with controlled ovarian stimulation
P. Bakas1, *(), M. Simopoulou1, P. Panagopoulos2, N. Salakos1, Ch. Siristatidis2
12nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens, Greece
23rd Department of Obstetrics and Gynecology, Attiko Hospital, University of Athens, Athens, Greece
Download:  PDF(432KB)  ( 195 ) Full text   ( 4 )
Export:  BibTeX | EndNote (RIS)      
Abstract  

Purpose of Investigation: To examine if the potential changes in progesterone (P) and estradiol (E2) levels during the luteal phase can predict the outcome in IVF/ICSI cycles. Material and Methods: A prospective study of 282 patients with infertility undergoing IVF/ICSI have been included. Serum E2 and P measurements at day of hCG triggering and days 6 and 10 after embryo transfer in conception and non-conception cycles. Results: The ROC curve in predicting clinical pregnancy was calculated at 0.864 (95% CI: 0.841-0.92). A maximum reduction of ≤ 32 % demonstrated sensitivity of 84.3% and specificity of 80.4%. The corresponding ROC curve for percentage change in P levels was 0.733 with 95% CI: 0.334-0.96. Conclusion: A maximum reduction of 32 % in E2 levels between days 6 and 10 after embryo transfer demonstrated a predictive ability for clinical pregnancy after IVF/ICSI of 86.4% with sensitivity 84.3% and specificity 80.4%.

Key words:  Estradiol      Progesterone      Ganirelix      Controlled ovarian stimulation      COS      IVF      ICSI     
Published:  10 October 2019     
*Corresponding Author(s):  P. BAKAS     E-mail:  pbakas74@gmail.com

Cite this article: 

P. Bakas, M. Simopoulou, P. Panagopoulos, N. Salakos, Ch. Siristatidis. Luteal phase progesterone and estradiol concentrations and their relation to the outcome of IVF/ICSI cycles with controlled ovarian stimulation. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 727-730.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4741.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I5/727

[1] Pelin Kutlu, Seda Karabulut, Oya Korkmaz. Administration of autologous platelet rich plasma and the impact on outcomes of assisted reproduction treatment in infertile women[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1025-1031.
[2] Yu Deng, Zhan-Hui Ou, Min-Na Yin, Pei-Ling Liang, Zhi-Heng Chen, Abraham Morse, Ling Sun. Age and anti-Műllerian hormone: prediction of cumulative pregnancy outcome in in vitro fertilization with diminished ovarian reserve[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 835-841.
[3] Aybike Pekin, Ayşe Gül Kebapçılar, Ersin Çintesun, Setenay Arzu Yılmaz, Özlem Seçilmiş Kerimoğlu. Comparison of an estradiol patch and GnRH-antagonist protocol with a letrozole/antagonist protocol for patients without oocyte development, fertilization and/or embryo development in previous IVF cycles[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 924-928.
[4] Nur Dokuzeylul Gungor, Kagan Güngör, Mustecep Kavrut, Arzu Yurci. A retrospective series of homologous intracytoplasmic sperm injection cycle results of 99 women with mosaic Turner syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 942-948.
[5] Sara Oday, Maysoon Sharief. The role of salivary progesterone and cervical length measurement in predicting risk of spontaneous preterm birth[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 509-513.
[6] Engin Turkgeldi, Sule Yildiz, Berk Angun, Bulent Urman, Baris Ata. Oocyte yield of GnRH antagonist cycles scheduled with a short course of estradiol in the early follicular phase[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 278-282.
[7] Guy Shrem, Nouf M. Alasmari, Jacques Balayla, Alexander Volodarsky-Perel, Weon-Young Son, Michael H. Dahan. Paternal age predicts live birth in women above 40 years of age undergoing in-vitro fertilization (IVF)[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 299-306.
[8] R. Duraker, E.S. Guvendag Guven, S. Dilbaz, A. Mentese, S. Aydın, S. Guven. Oxidative stress status in severe OHSS patients who underwent long agonist protocol intracytoplasmic sperm injection cycles[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 312-316.
[9] Seda Karabulut, Pelin Kutlu, Oya Korkmaz, M. Volkan Bülbül, İlknur Keskin. Fresh versus frozen blastocyst transfer outcomes deriven from the same ICSI cycle in male factor infertility[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 331-335.
[10] Gregory W. Kirschen , Samantha M. Dayton, Sophia Blakey-Cheung, Michael L. Pearl. Which patients on a gynecologic oncology service will require perioperative transfusion? A single-center retrospective cohort study[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 47-52.
[11] Ji Eun Park, Ji Kwon Park, Hyun Chul Jo, In Ae Cho, Jong Chul Baek. The association between antenatal corticosteroid use in late-preterm and early-term pregnancy and nonreassuring fetal status[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 79-84.
[12] I. Thanaboonyawat, P. Chera-aree, S. Petyim, R. Choavaratana, P. Laokirkkiat. The effect of three-month topical testosterone gel application on semen quality in men with oligozoospermia and low serum testosterone levels[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 875-881.
[13] M. Elmahdy, I. Elfourtia, H. Maghraby. Office hysteroscopy in cases of recurrent implantation failure; Do or not to do[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 723-728.
[14] Z. Merhi, J. Zhang. At-Home IVF Kit: application during the COVID-19 pandemic[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 653-659.
[15] C. Ji, L.J. Sun, L.T. Li, J. Ma, W.H. Ge, X. Zhao. Impact of clinical pharmacist intervention on blood glucose control and perinatal outcomes in gestational diabetes mellitus through a diabetes management system[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(5): 645-652.
No Suggested Reading articles found!