Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 713-722    DOI: 10.12891/ceog4711.2019
Original Research Previous articles | Next articles
Preliminary analysis of risk factors for congenital heart disease: a retrospective review of 145 cases in a single institution
Qianhong Liang1, *(), Wei Gong1, Dongming Zheng1, Risheng Zhong1, Yunjie Wen2, Xiaodan Wang2
1Ultrasound Department, China Panyu He Xian Memorial Hospital, Guangzhou, China
2Guangzhou Huayin Medical Labratory Center CO. Ltd, Guangzhou, China
Download:  PDF(410KB)  ( 190 ) Full text   ( 5 )
Export:  BibTeX | EndNote (RIS)      
Abstract  

Background: Congenital anomaly is one of the most common cause of infant mortality and in China the incidence is quite high compared to other countries. It is therefore important to identify the potential risk factors of congenital problem such as congenital heart diseases. Materials and Methods: A retrospective study of 5,636 newborn cases from 2012 to 2014 in Panyu Maternal and Child Care Service Centre of Guangzhou was carried out, and among which 145 cases were confirmed for congenital heart defects. Review and analysis of maternal and paternal factors was performed using univariate and multivariate logistic regression analyses. Results: Several maternal factors were significantly associated with the occurrence of the congenital anomaly. However, after combining both maternal and paternal factors, only higher maternal age (OR = 1.076, 95% CI: 1.007-1.148, p = 0.029) and increased gravidity (OR = 1.153, 95% CI: 1.024-1.298, p = 0.018) were identified as risk factors whereas RBC count (OR = 0.374, 95% CI: 0.187-0.745, p = 0.005) was identified as a protective factor of the abnormal outcome using multivariate regression analysis. Conclusion: Further investigation on how the level of RBC in mother may contribute to the prevention of congenital heart disease is warranted.

Key words:  Congenital heart disease      Regression analysis      Maternal factor      Paternal factor      Retrospective analysis      Red blood cell count     
Published:  10 October 2019     
*Corresponding Author(s):  QIANHONG LIANG     E-mail:  luluoj792@tom.com

Cite this article: 

Qianhong Liang, Wei Gong, Dongming Zheng, Risheng Zhong, Yunjie Wen, Xiaodan Wang. Preliminary analysis of risk factors for congenital heart disease: a retrospective review of 145 cases in a single institution. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 713-722.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4711.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I5/713

[1] F.Q. Ma, G.Y. Zhang, J.B. Gao, C. Fang, Y. Bo, G.Y. Huang, A.H. Zhang. Clinical screening method and risk factors’ analysis of congenital cardiovascular defects: a case control study from a Chinese local region[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 515-520.
[2] E. Ricci, F. Chiaffarino, S. Cipriani, R. Cioffi, P. Viganò, E. Garavaglia, F. Parazzini. Wine, spirits, and beer intake and endometriosis risk among infertile women: results from a case control study[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 548-551.
[3] M. S. Arnaout, M. Serhan, C. Saade. A case of a 42-year-old patient with anomalous origin of the left main coronary artery from the pulmonary artery who delivered three times with no complications: presentation, diagnosis, and review[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(6): 889-892.
[4] S. Plešinac, I. Pilić, I. Babović. Pregnancy after heart surgery – challenges[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(1): 48-51.
[5] L. Liu, Y. He, Z. Li, L. Zhang. Application of two-dimensional echocardiography combined with enhanced flow in diagnosing fetal heart malformation[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(2): 195-201.
[6] I. Felesakis, E. Kontomanolis, P. Dalla, A. Liberis, G. Galazios, V. Liberis. Syndrome of hypoplastic left heart: a case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(1): 100-101.
[7] J. Ma, W. Zhao, R.M. Ma, X.J. Li, Z.H. Wen, X.F. Liu, W.D. Hu, C.B. Zhang. Investigation on maternal physiological and psychological factors of cheilopalatognathus[J]. Clinical and Experimental Obstetrics & Gynecology, 2013, 40(3): 384-388.
[8] R. Axt-Fliedner, H. J. Hendrik, M. Wrobel, M. Friedrich, W. Schmidt,. Significance of high and normal neonatal nucleated red blood cell count in small-for-gestational-age newborns[J]. Clinical and Experimental Obstetrics & Gynecology, 2002, 29(1): 49-53.
[9] R. Axt-Fliedner, M. Wrobel, H.J. Hendrik, A. K. Ertan, D. Mink, J. Konig, W. Schmidt. Nucleated red blood cell count and Doppler ultrasound in low- and high-risk pregnancies[J]. Clinical and Experimental Obstetrics & Gynecology, 2000, 27(2): 85-88.
[10] A. GIANCOTTI, F. TORCIA, G. GIAMPA, G. GALLO, F. GALLO, L. DONATI, D. DE SANTO. Prenatal evaluation of congenital heart disease in high-risk pregnancies[J]. Clinical and Experimental Obstetrics & Gynecology, 1995, 22(3): 225-229.
[11] G. Loverro, P. Greco, G. Balducci, G. Caruso, L. Selvaggi. Ultrasonic and postnatal findings in left visceral isomerism[J]. Clinical and Experimental Obstetrics & Gynecology, 1991, 18(2): 75-80.
No Suggested Reading articles found!