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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (1): 127-130    DOI: 10.12891/ceog4552.2019
Original Research Previous articles | Next articles
Assessment of ovarian reserve with anti-Mullerian hormone in women following allogeneic hematopoietic cell transplantation
A.H. Kaya1, *(), E. Tekgunduz1, S. Akpınar1, G. Bozdağ2, T.N. Yiğenoğlu1, A. Merdin1, S. Namdaroglu1, O. Kayıkcı1, F. Altuntaş1
1 Hematology Clinic and Bone Marrow Transplantation Unit, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey
2 Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey
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Abstract  
Introduction: Severe ovarian failure and persistent infertility have could be seen in females following allogeneic hematopoietic cell transplantation (allo-HCT.) In this study, the authors aimed to determine the effectiveness of AMH on assessment of ovarian reserve in long-term survivors after allo-HCT. Material and Methods: Female patients, who underwent allo-HCT between August 2009 and February 2016, were retrospectively evaluated for ovarian capacity in long-term follow-up. Twenty-one female patients with a median age of 34 (22-45) years were included in the study. The serum levels of estrogen (E2), follicle stimulated hormone (FSH), luteinizing hormone (LH), and AMH were analysed. Results: The median duration of post-transplant follow-up was 37 (12-84) months. Primary ovarian failure (POF) was detected in eight (38,1%) and 19 (90,4%) cases in the pre-transplant and post-transplant period, respectively. It was found that no menstruation cycles were observed in 18 cases with low AMH levels. Discussion: Regular menstrual cycles may not guarantee the fertilization in the post-transplant period. Combined analysis of hormonal investigations, antral follicle count by vaginal USG, and evaluation of serum AMH levels may be preferred to demonstrate the presence of POF.
Key words:  Anti-Mullerian hormone      Ovarian reserve      Allogeneic stem cell transplantation     
Published:  10 February 2019     
*Corresponding Author(s):  A.H. KAYA     E-mail:  dr.alihakan@gmail.com

Cite this article: 

A.H. Kaya, E. Tekgunduz, S. Akpınar, G. Bozdağ, T.N. Yiğenoğlu, A. Merdin, S. Namdaroglu, O. Kayıkcı, F. Altuntaş. Assessment of ovarian reserve with anti-Mullerian hormone in women following allogeneic hematopoietic cell transplantation. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 127-130.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4552.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I1/127

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[2] Aybike Pekin, Ayşe Gül Kebapçılar, Ersin Çintesun, Setenay Arzu Yılmaz, Özlem Seçilmiş Kerimoğlu. Comparison of an estradiol patch and GnRH-antagonist protocol with a letrozole/antagonist protocol for patients without oocyte development, fertilization and/or embryo development in previous IVF cycles[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 924-928.
[3] H. Saleh, F. Moiety, A.F. Agameya, Y. Elkassar, R.M. El Sharakwy, D. Zeidan, H. Elmeligy. Comparison between antral follicle count and anti-Müllerian hormonal level in the prediction of ovarian response and pregnancy outcome in intracytoplasmic sperm injection patients: implications in personalizing ovarian stimulation[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 166-173.
[4] Hue HJ, Kim SK, Choi JY, Suh DH, Kim KD, No JH, Lee JR, Jee BC, Kim YB, Jeon HW. Previous ovarian surgery increases the risk of tubal factor infertility[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 84-88.
[5] N. Eamudomkarn, L. Salang, K. Seejorn, P. Kleebkaow. Comparison of impact on ovarian reserve between laparoscopic and laparotomy ovarian cystectomy[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 779-783.
[6] L.-S. Wang, X.-L. Zhao, X.-A. Cai, G.-F. Fu. Age specific reference intervals of serum anti-Müllerian hormone concentration of 1,253 women with healthy females in infertility center[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 526-530.
[7] J. Micic, L. Surlan, J. Dotlic, N. Milic, S. Vidakovic, N. Radunovic. Ovarian response predictive model in different controlled ovarian stimulation protocols for IVF/ICSI treatment[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 923-928.
[8] H.U. Yuvacı, S. Uysal, H. Haltaş, B. Sırav, C.I. Duvan, N. Turhan, N. Seyhan. The effect of non-ionizing radiation on the ovarian reserves of female rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(4): 605-610.
[9] A. Eser, D. Hizli, M. Namuslu, H. Haltas, N. Kosus, A. Kosus, H. Kafali. Protective effect of curcumin on ovarian reserve in a rat ischemia model: an experimental study[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(3): 453-457.
[10] Wei Wang, Yan-Qing Wang, Ying-Ying Qin, Yu-Jie Dang, Ming-Di Xia, Ying Ma, Yu-Lan Mu. The feasibility of establishing classification system for ovarian function[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(5): 631-637.
[11] B. Vural, Y. Çakıroğlu, F. Vural. The predictor markers of ovarian response in poor responders under 40 years of age[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(5): 650-653.
[12] T. Aydin, M. Kara, T. Aran, N. Turktekin, B. Ozdemir. The association between anti-Mullerian hormone and IVF-ICSI outcome in poor responder patients performing long protocol[J]. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(5): 663-665.
[13] N. Thomakos, S.P. Trachana, I. Koutroumpa, A. Rodolakis, N.G. Gavalas. Molecular aspects and clinical methods for preserving ovarian reserves in women receiving cancer treatment[J]. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(4): 416-425.
[14] Xin-hua Yang, Fei Ji, AiXingZi. AiLi, HaNiKeZi. TuerXun, Yan He, Yan Ding. Effects of laparoscopic ovarian endometriosis cystectomy combined with postoperative GnRH-a therapy on ovarian reserve, pregnancy, and outcome recurrence[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(3): 272-275.
[15] E. Poli, S. Manfé, D. Capuzzo, S. Gava, F. Viganò, M.L. Coronella, M. Gangemi. DHEA pre-treated patients, poor responders to a first IVF (ICSI) cycle: clinical results[J]. Clinical and Experimental Obstetrics & Gynecology, 2014, 41(1): 5-9.
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