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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (1): 81-84    DOI: 10.12891/ceog4364.2019
Original Research Previous articles | Next articles
The efficacy and safety of intravaginal misoprostol for the induction of labor in patients with obstetrical or medical indication for labor induction
E. Pereira Alves Filho1, F.C. Nogueira Arcanjo1, *(), A.R. Mesquita Rocha1, D. Frade Bernardes1, M.H. Oliveira Santos1, N.L. Pereira Coutinho1
1 Universidade Federal do Ceará, Campus Sobral, Sobral, Ceará, Brazil
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Abstract  
Background: Labor induction is becoming one of the most frequent procedures in maternity hospitals. However, the optimal agent for labor induction has not yet been established. Misoprostol, a prostaglandin E1 analogue, is receiving much attention due to its labor induction properties. Objective: The aim of this study was to evaluate the efficacy and safety of 25 and 50 mcg of intravaginal misoprostol, every four hours, for the induction of labor. Materials and Methods: This was a randomized controlled study to compare two different regimens of vaginal misoprostol, in women with obstetrical or medical indication for induction of labor. Participants received either a 25- or 50-mcg dose of misoprostol inserted into the posterior vaginal fornix repeated every four hours (maximum six doses), until adequate labor was established. Close monitoring of uterine activity and fetal heart rate was performed in all patients. Data were collected prospectively on epidemiological, obstetric, and care aspects. Results: Both regimens of misoprostol were effective in the induction of labor and most of the women had normal vaginal deliveries (81.08%). Although the mean time intervals from induction to the onset of active labor, and from induction to vaginal delivery for the 50-mcg regimen were lower, there was no significant difference between the two regimens. There were very few complications, with one case of uterine tachysystole in each treatment regimen. Conclusion: The results of the present study show that both regimens of misoprostol appear to be effective for the induction of labor in patients with indication, with few fetal complications.
Key words:  Cervical ripening      Labor      Induced      Administration      Intravaginal      Misoprostol     
Published:  10 February 2019     
*Corresponding Author(s):  F.C. NOGUEIRA ARCANJO     E-mail:  prhsobral@gmail.com

Cite this article: 

E. Pereira Alves Filho, F.C. Nogueira Arcanjo, A.R. Mesquita Rocha, D. Frade Bernardes, M.H. Oliveira Santos, N.L. Pereira Coutinho. The efficacy and safety of intravaginal misoprostol for the induction of labor in patients with obstetrical or medical indication for labor induction. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 81-84.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4364.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I1/81

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