Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (1): 12-15    DOI: 10.12891/ceog4117.2019
Original Research Previous articles | Next articles
The relationship between vitamin D and IVF: a systematic review and meta-analysis
Chunjuan Shen1, Liping Wang1, *(), Xiaojie Wu1, Shuhui Mao1, Chunxia Fang1
1 Department of Obstetrics and Gynecology, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China
Download:  PDF(1170KB)  ( 231 ) Full text   ( 12 )
Export:  BibTeX | EndNote (RIS)      
Abstract  
Vitamin D deficiency does not influence IVF outcomes, but is related to lower pregnancy and it is important to provide more reliable evidence on vitamin D in IVF due o the published studies which are strongly contradictory. Objectives: To explore the effect of vitamin D in IVF with a focus on the outcome of clinical pregnancy in published studies. Materials and Methods: The authors used PubMed, EMBASE, Web of knowledge (SCI), and Cochrane Library Methods to explore all studies that evaluate vitamin D levels and IVF outcomes until 2016. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated for analyses. Result: The authors first classified two groups to investigate the influence of vitamin D in IVF. There was no significant difference with deficient vitamin D and IVF outcome (RR 0.88, 95% CI 0.74-1.04; I2 63%, seven trials; 1,865 participants). In addition, vitamin D deficiency also di not show a significant difference in IVF outcome (RR 0.91, 95 % CI 0.77–1.18, RR 0.91, 95% CI, 0.77-1.18; I2, 72 trials, 1,172 participants). Conclusion: There is no significance between vitamin D status (deficiency or replete) and IVF outcomes, but it was also found that vitamin D deficiency was inclined to lower IVF pregnancy outcome.
Key words:  Vitamin D deficient      vitamin D replete      IVF      Clinical pregnancy rate      Endometrium      Infertility      Embryo transfer      Cut-off values     
Published:  10 February 2019     
*Corresponding Author(s):  LIPING WANG     E-mail:  87604211@qq.com

Cite this article: 

Chunjuan Shen, Liping Wang, Xiaojie Wu, Shuhui Mao, Chunxia Fang. The relationship between vitamin D and IVF: a systematic review and meta-analysis. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 12-15.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4117.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I1/12

[1] Pelin Kutlu, Seda Karabulut, Oya Korkmaz. Administration of autologous platelet rich plasma and the impact on outcomes of assisted reproduction treatment in infertile women[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1025-1031.
[2] Chang Liu, Minchen Dai, Lei Zhao, Fangfang Wang. The effects of Chinese herbal medicine on the pregnancy outcomes of infertile women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review and meta-analysis[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1032-1043.
[3] Arzu Yurci, Nur Dokuzeylul Gungor, Tugba Gurbuz. Defective expression of endometrial BMP-2 contributes to subfertility in women with unexplained infertility[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1094-1098.
[4] Lorenz Hinterleitner, Herbert Kiss, Johannes Ott. The impact of Cesarean section on female fertility: a narrative review[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 781-786.
[5] Sema Karakaş, Cihan Kaya, Sebastian Daniel Schäfer, Mislav Mikuš, Milan Terzic, Bekhzod Abdullaev, Alessandra Andrisani. Fertility-sparing in cancer patients[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 787-794.
[6] Zhongying Huang, Zhun Xiao, Qianhong Ma, Yu Bai, Feilang Li. Efficacy of tamoxifen for infertile women with thin endometrium undergoing frozen embryo transfer: a meta-analysis[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 806-811.
[7] Yu Deng, Zhan-Hui Ou, Min-Na Yin, Pei-Ling Liang, Zhi-Heng Chen, Abraham Morse, Ling Sun. Age and anti-Műllerian hormone: prediction of cumulative pregnancy outcome in in vitro fertilization with diminished ovarian reserve[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 835-841.
[8] Nur Dokuzeylul Gungor, Kagan Güngör, Mustecep Kavrut, Arzu Yurci. A retrospective series of homologous intracytoplasmic sperm injection cycle results of 99 women with mosaic Turner syndrome[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 942-948.
[9] Martin Klein, Lenka Lapides, Denisa Fecmanová, Ivan Varga. Novel cellular entities and their role in the etiopathogenesis of female idiopathic infertility—a review article[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 461-465.
[10] Banuhan Şahin, Buğra Şahin, Pervin Karlı, Görker Sel, Şafak Hatırnaz, Osman Fadıl Kara, Andrea Tinelli. Level of depression and hopelessness among women with infertility during the outbreak of COVID-19: a cross-sectional investigation[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 594-600.
[11] Arzu Yurci, Aret Kamar, Nurettin Turktekin, Ramazan Ozyurt. Comparison of immediate versus delayed frozen embryo transfer on reproductive outcome[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 263-269.
[12] Guy Shrem, Nouf M. Alasmari, Jacques Balayla, Alexander Volodarsky-Perel, Weon-Young Son, Michael H. Dahan. Paternal age predicts live birth in women above 40 years of age undergoing in-vitro fertilization (IVF)[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 299-306.
[13] R. Duraker, E.S. Guvendag Guven, S. Dilbaz, A. Mentese, S. Aydın, S. Guven. Oxidative stress status in severe OHSS patients who underwent long agonist protocol intracytoplasmic sperm injection cycles[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 312-316.
[14] A. Yaylalı, M. Bakacak, Z. Bakacak, F. Tolun. An investigation of the effects on follicular-embryonal development and pregnancy outcomes of serum and follicular fluid ischemia-modified albumin in cases of unexplained infertility receiving in vitro fertilization treatment[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 835-839.
[15] I. Thanaboonyawat, P. Chera-aree, S. Petyim, R. Choavaratana, P. Laokirkkiat. The effect of three-month topical testosterone gel application on semen quality in men with oligozoospermia and low serum testosterone levels[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 875-881.
No Suggested Reading articles found!