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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (3): 433-436    DOI: 10.12891/ceog4368.2018
Original Research Previous articles | Next articles
Tertiary lymphatic organs of the female pelvis: not negligible structures
L. Roncati1, *(), A. Manenti1
1 Departments of Diagnostic and Clinical Medicine and of Surgery, University of Modena and Reggio Emilia, Modena, Italy
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Abstract  
Introduction: The lymphatic organs are subdivided in primary, secondary, and tertiary. The latter are scantly known structures, typically containing far fewer lymphocytes, imported from blood and lymph, which can be found theoretically in any abdominal or extraabdominal site. The present authors' intent was to search them in the mesentery and peritoneum of the female pelvis, in order to trace a possible line of evolution towards more mature lymphatic organs, and to evaluate their immune arrangement. Materials And Methods: The authors also investigated the normal mesentery and peritoneum, obtained from ten surgical specimens of hysterectomy with bilateral salpingo-oophorectomy, performed for symptomatic uterine prolapse, in patients aged between 60 and 70 years. After routine procedures of diagnosis and staging, the representative lymphatic tissue was submitted to immunohistochemical characterization for CD20, CD3, CD4, CD8, CD56, CD68, CD138, and podoplanin. Results: The authors were able to recognize in a simple aggregate of lymphocytes, gathered around a capillary or arteriola, the primordial nucleus of the tertiary lymphatic organ. Over time, this microaggregate increases in size and volume for the accumulation of lymphocytes, until it reaches the final conformation of a small lymph node, equipped with a thin capsule and a proper hilus. Its core is represented by CD20+ B lymphocytes, while CD3+ T lymphocytes are less numerous and almost exclusively represented by CD4+ T-helper lymphocytes, being the CD3+ T-cytotoxic reduced to a minimum percentage. At its periphery, some CD68+ histocytes can be also observed; no CD56+ NK lymphocytes, neither CD138+ plasma cells were detected. Moreover, the immunohistochemistry for D2-40 did not reveal significant neolymphangiogenesis. Conclusion: Tertiary lymphatic organs can be considered a reserve system, ready to replace the lymph nodes, when they become aged or inefficient, or when their increase in number is requested. Therefore, the tertiary lymphatic organs of the female pelvis can be thought as potential defenders against infections or cancer. However, they can be involved by metastases at any stage of their development, an event that testifies an intrinsic immune immaturity. Also, this secondary neoplastic colonization can be suspected as a key step towards peritoneal carcinomatosis, because the tertiary lymphatic organs can integrate in the lymph dynamics of the female pelvis and peritoneal cavity.
Key words:  Tertiary lymphatic organs      Female pelvis      Immunohistochemistry     
Published:  10 June 2018     
*Corresponding Author(s):  L. RONCATI     E-mail:  emailmedical@gmail.com

Cite this article: 

L. Roncati, A. Manenti. Tertiary lymphatic organs of the female pelvis: not negligible structures. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(3): 433-436.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4368.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I3/433

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[5] İ. Ceylan, T. Peker, N. Coşkun, S. Ömeroğlu, A. Poyraz. Uterus and myoma histomorphology[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(5): 710-715.
[6] O. Erol, D. Süren, H.Y. Ellidağ, G.A. Bülbül, A.U. Derbent, R. Elal, D. Özel, C. Sezer, N. Yılmaz. Serum level and placental expression of resistin in pregnancies complicated by preeclampsia: relationship with disease severity[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(4): 516-521.
[7] R. Bedir, I. Sehitoglu, G. Balik, M. Kagitci, H. Gucer, C. Yurdakul, P. Bagci. The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(3): 463-466.
[8] X. Yu, H. Ren, T. Liu, M. Yong, H. Zhong. Expression and significance of ERβ and TrkB in endometriosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(1): 75-81.
[9] T. Özçakır, M.A. Turan, F. Şimşek, C. Atay, S. Vatansever, K. Özbilgin. A comparison of the molecular distribution of proangiogenic factors in endometrium of missed abortions and of voluntary first trimester termination cases[J]. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(1): 40-48.
[10] A. Kondi-Pafiti, M. Frangou-Plemmenou, C. Bakalianou, M. Tsantopoulos, K. Papadias, A. Liapis. Lesions of the subepithelial stromal zone of the lower female genital tract. An immunopathological study[J]. Clinical and Experimental Obstetrics & Gynecology, 2009, 36(4): 226-229.
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[12] E. Brizzi, R. De Caro, E. Sgambati, G. C. Todescan, P. F. Munari. The organization of subperitoneal connective tissue in the female pelvis[J]. Clinical and Experimental Obstetrics & Gynecology, 1994, 21(4): 253-258.
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