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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (2): 209-213    DOI: 10.12891/ceog3912.2018
Original Research Previous articles | Next articles
Supplementation of IVF solutions with melatonin improves assisted reproductive technology results
Bo Ma1, *(), Yuhu Li1, Xiulan Zhang1, Liuguang Zhang1, Ning Li1, Ping Yu1
1 IVF Center, Mali Hospital, Haikou, China
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Abstract  
Aim: To evaluate the effects of melatonin supplementation of culture medium on the sperm survival rate, fertilization rate, cleavage rate, optimal embryo rate, blastocyst rate, implantation rate and clinical pregnancy rate. Material and Methods: Oocytes and sperm obtained from each patient (86 patients in total) were divided on average into four groups with different concentrations of melatonin (0 nmol/L, 0.1 nmol/L, 1.0 nmol/L, and 10.0 nmol/L). Melatonin was supplemented three times a day to maintain the concentration in different groups, and all the results were recorded at each related time. Results: The results indicated that melatonin could increase sperm survival rate, fertilization rate, and cleavage rate, and the solutions with 10 nmol/L melatonin were most effective (p < 0.05). Lower concentration of melatonin (0.1 nmol/L) might have negative effect on the fertilization rate. Melatonin could improve significantly optimal embryo rate, blastocyst rate, implantation rate, and clinical pregnancy rate (p < 0.05) and the peak values all appeared in the treatment group with 1.0 nmol/L melatonin. Conclusions: Addition of 1.0 nmol/L melatonin into culture media was the most effective to improve embryo quality and clinical outcome of IVF.
Key words:  Melatonin      IVF      Fertilization rate      Embryo      Clinical pregnancy rate     
Published:  10 April 2018     
*Corresponding Author(s):  BO MA     E-mail:  mb253000@163.com

Cite this article: 

Bo Ma, Yuhu Li, Xiulan Zhang, Liuguang Zhang, Ning Li, Ping Yu. Supplementation of IVF solutions with melatonin improves assisted reproductive technology results. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 209-213.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3912.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I2/209

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