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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (2): 204-208    DOI: 10.12891/ceog3913.2018
Original Research Previous articles | Next articles
Increased kisspeptin mRNA expression derived from abnormally adhered placenta: compensatory inhibition of abnormal placental invasion?
A. Tsiola1, D. Marioli2, 3, I. Papadimitriou2, V. Tsapanos2, N. A. Georgopoulos2, 3, *()
1 Ministry of Justice, Transparency and Human Rights, Department of Forensic Medicine of Patras, Rio, Greece
2 Department of Obstetrics and Gynecology, University of Patras Medical School, Rio, Greece
3 Division of Reproductive Endocrinology, University of Patras Medical School, Rio, Greece
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Abstract  
Purpose of investigation: In normal conditions, circulating kisspeptin levels dramatically increase during the first trimester of pregnancy and fall approximately five days post-delivery to concentrations comparable to those detected prior to pregnancy. Dysregulation of trophoblast invasion results in a wide spectrum of abnormal pregnancies such as preeclampsia, premature delivery, and choriocarcinoma. The aim of the present study was to investigate the expression profile of KiSS-1 in abnormally adherent placenta specimens (placenta accreta and placenta praevia). Materials and Methods: Ten term trophoblast preparations (five normal adhesions, four placenta accretae and one placenta praevia) were obtained for RNA extraction and immunohistochemistry in order to determine KiSS-1 mRNA and protein levels. Results: KiSS-1 mRNA expression was found to be increased in conditions of pathological placental adhesion compared to normal tissues. Conclusion: KiSS-1 is implicated in the regulation of placental invasion as part of a compensatory inhibition to abnormal placental adhesion.
Key words:  Kisspeptin      Placenta      Placenta accreta     
Published:  10 April 2018     
*Corresponding Author(s):  N.A. GEORGOPOULOS     E-mail:  neoklisg@hol.gr

Cite this article: 

A. Tsiola, D. Marioli, I. Papadimitriou, V. Tsapanos, N. A. Georgopoulos. Increased kisspeptin mRNA expression derived from abnormally adhered placenta: compensatory inhibition of abnormal placental invasion?. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(2): 204-208.

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https://ceog.imrpress.com/EN/10.12891/ceog3913.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I2/204

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