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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (3): 697-699    DOI: 10.31083/j.ceog.2021.03.2376
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Two successful pregnancies after a simultaneous kidney and pancreas transplantation for type 1 diabetes mellitus-complicated nephropathy
Elisa Casella1, Carla Ettore1, Ferdinando Antonio Gulino1, *(), Elisa Pappalardo1, Filippo Rapisarda1, Stella Capriglione2, Giuseppe Ettore1
1Department of Obstetrics and Gynaecology-Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Garibaldi Nesima, 95122 Catania, Italy
2Department of Obstetrics and Gynecology-Istituto per la Sicurezza Sociale, 47893 Cailungo-Borgo Maggiore, Repubblica di San Marino
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Abstract  
Background: Simultaneous kidney and pancreas transplantation (SKPT) is the treatment of choice for patients with type 1 diabetes mellitus and end-stage renal disease. A successful transplantation result in improved functional status, health-related quality of life and reproductive health. The most significant factors for successful outcomes for mother and child are stable pre-pregnancy transplant function tests and absence of immunosuppressive therapy. Pregnancy after transplantation is a high-risk condition; it should be carefully considered, planned, and monitored by a multidisciplinary health care team. Case presentation: We describe a case report of a 40 years old woman, how had two successful pregnancies after a simultaneous kidney and pancreas transplantation. Her pregnancy course was uneventful until 34 weeks of gestation when she had pre-eclampsia in the first pregnancy and PPROM in the second pregnancy. Conclusion: Scientific data about simultaneous kidney and pancreas transplantation are yet limited, so it is difficult to build guidelines in this clinical condition. We describe in literature the first case of two successful pregnancy after SKPT. Both babies had a low birth weight in coincidence with lower gestational age and in the first pregnancy, the mother developed preeclampsia.
Key words:  Diabetes      Preeclampsia      Pregnancy      Transplant     
Submitted:  23 November 2020      Revised:  11 January 2021      Accepted:  18 January 2021      Published:  15 June 2021     
*Corresponding Author(s):  Ferdinando Antonio Gulino     E-mail:  docferdi@hotmail.it

Cite this article: 

Elisa Casella, Carla Ettore, Ferdinando Antonio Gulino, Elisa Pappalardo, Filippo Rapisarda, Stella Capriglione, Giuseppe Ettore. Two successful pregnancies after a simultaneous kidney and pancreas transplantation for type 1 diabetes mellitus-complicated nephropathy. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 697-699.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.03.2376     OR     https://ceog.imrpress.com/EN/Y2021/V48/I3/697

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