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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (2): 359-364    DOI: 10.31083/j.ceog.2021.02.2297
Original Research Previous articles | Next articles
Value of computed tomography-defined visceral fat area as a risk factor for endometrial cancer
Jae-hyun Cho1, Jeong Sig Kim1, *(), Suyeon Park2, Woo Young Kim3
1Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, 04401 Seoul, Republic of Korea
2Department of Biostatistics, Soonchunhyang University College of Medicine, 04401 Seoul, Republic of Korea
3Department of Obstetrics & Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 03181 Seoul, Republic of Korea
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Abstract  
Objective: Obesity is a risk factor for endometrial cancer. Recently, visceral fat is strongly associated with obesity-related carcinogenesis, more than subcutaneous fat. In this study, we hypothesized that the visceral fat measured by computed tomography (CT) contributes to the occurrence of endometrial cancer. Methods: A retrospective chart review of patients undergoing primary surgery for endometrial cancer was conducted. The volume of visceral fat was measured by CT scans performed at the fourth lumbar level for all participants. Body fat distributions assessed by a direct method in 52 endometrial cancer cases were compared with those of age- and BMI-matched healthy community controls. Results: Case group showed significantly higher mean visceral fat area (VFA; 76.2 ± 25.0 vs. 62.2 ± 13.9 cm2, P = 0.007). The mean total fat area (TFA; 270.3 ± 99.9 vs. 238.9 ± 53.8 cm2, P = 0.137) and subcutaneous fat area (SFA; 194.2 ± 86.5 vs. 176.7 ± 45.8 cm2, P = 0.315), however, presents no significant differences. VFA showed lower correlation with BMI (r2 = 0.299, P < 0.001) than to SFA (r2 = 0.528, P < 0.001) or TFA (r2 = 0.584, P < 0.001). In receiver operator characteristic (ROC) curve, at a VFA value of 70.8 cm2, sensitivity and specificity of the case group was 55.8% and 75%, respectively. Conclusion: Increased abdominal visceral fat is associated with endometrial cancer risk and can be predicted by measuring CT scans. Furthermore, as the most independent factor of BMI, VFA may provide additional information for representative risks of endometrial cancer.
Key words:  Intra-abdominal fat      Computed tomography      Body fat distribution      Endometrial neoplasms     
Submitted:  17 September 2020      Revised:  07 December 2020      Accepted:  11 December 2020      Published:  15 April 2021     
Fund: 
NRF-2020R1A2C1102244/Soonchunhyang University Research Fund and the National Research Foundation of Korea (NRF) funded by the Ministry of Education
*Corresponding Author(s):  Jeong Sig Kim     E-mail:  jskim@schmc.ac.kr

Cite this article: 

Jae-hyun Cho, Jeong Sig Kim, Suyeon Park, Woo Young Kim. Value of computed tomography-defined visceral fat area as a risk factor for endometrial cancer. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 359-364.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.02.2297     OR     https://ceog.imrpress.com/EN/Y2021/V48/I2/359

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