Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (2): 278-282    DOI: 10.31083/j.ceog.2021.02.2225
Original Research Previous articles | Next articles
Oocyte yield of GnRH antagonist cycles scheduled with a short course of estradiol in the early follicular phase
Engin Turkgeldi1, Sule Yildiz1, Berk Angun2, Bulent Urman3, Baris Ata1, 3, *()
1Department of Obstetrics and Gynecology, Koc University Hospital, 34010 Istanbul, Turkey
2Dunya IVF Clinic, 9200 Kyrenia, North Cyprus
3Department of Obstetrics and Gynecology, Koc University Faculty of Medicine, 34010 Istanbul, Turkey
Download:  PDF(169KB)  ( 145 ) Full text   ( 15 )
Export:  BibTeX | EndNote (RIS)      
Abstract  
Scheduling in vitro fertilization cycles enables planning oocyte retrieval and embryology procedures in order to suit both patients' and medical staff's needs. Current methods to schedule ovarian stimulation cycles are either cumbersome, costly or provide minor flexibility. The aim of this study was to investigate if scheduling gonadotropin releasing hormone (GnRH) antagonist cycles with a short course of estradiol in the early follicular phase affects oocyte yield. Fifty-nine oocyte donors undergoing two GnRH antagonist stimulation cycles within 6 months, one with and one without follicular phase estradiol scheduling (FES), serving as their own control were included in this retrospective cohort study. FES was achieved by giving 6 mg/day estradiol valerate orally from the 2nd–3rd day of menstrual cycle until the desired day of gonadotropin start. Main outcome measures were number of cumulus oocyte complexes and metaphase two oocytes. A total of 118 cycles, 59 FES and 59 unscheduled GnRH antagonist, were included. Median duration of estradiol administration was 3 days in FES cycles. In the FES group, stimulation lasted significantly longer by one day (11 vs 10 days, P = 0.03) and total gonadotropin consumption (2497 vs 2404 IU, P = 0.03) was statistically significantly higher, albeit minimal absolute difference, which is probably short of clinical significance. Numbers of COC (21 vs 20) and metaphase-two oocytes (17 vs 17) were similar between the two groups. In conclusion, FES does not require planning in advance and involves shorter use of estradiol/oral contraceptive tablets and can be advantageous to scheduling with luteal estradiol/oral contraceptive administration.
Key words:  Assisted reproduction      Cycle scheduling      Estradiol      GnRH antagonist      In vitro fertilization     
Submitted:  16 July 2020      Revised:  03 September 2020      Accepted:  16 September 2020      Published:  15 April 2021     
*Corresponding Author(s):  Baris Ata     E-mail:  barisata@ku.edu.tr

Cite this article: 

Engin Turkgeldi, Sule Yildiz, Berk Angun, Bulent Urman, Baris Ata. Oocyte yield of GnRH antagonist cycles scheduled with a short course of estradiol in the early follicular phase. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 278-282.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2021.02.2225     OR     https://ceog.imrpress.com/EN/Y2021/V48/I2/278

[1] Basilio Pecorino, Giuseppe Scibilia, Placido Borzì, Maria Elena Vento, Pierfrancesco Veroux, Paolo Scollo. Diminished ovarian reserve and ectopic ovaries in patients with Mayer-Rokitansky-Küster-Hauser syndrome candidates for Uterus Transplantation: our experience[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 907-912.
[2] Aybike Pekin, Ayşe Gül Kebapçılar, Ersin Çintesun, Setenay Arzu Yılmaz, Özlem Seçilmiş Kerimoğlu. Comparison of an estradiol patch and GnRH-antagonist protocol with a letrozole/antagonist protocol for patients without oocyte development, fertilization and/or embryo development in previous IVF cycles[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 924-928.
[3] Mahvash Zargar, Razieh Pazhouhanfar, Mahin Najafian, Parastoo Moradi Choghakabodi. Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 179-184.
[4] I. Thanaboonyawat, P. Chera-aree, S. Petyim, R. Choavaratana, P. Laokirkkiat. The effect of three-month topical testosterone gel application on semen quality in men with oligozoospermia and low serum testosterone levels[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 875-881.
[5] T. Hasegawa, K. Nakagawa, R. Sugiyama, N. Kuji, H. Nishi. Separate transfer of two frozen-thawed embryos reduces multiple gestations in assisted reproductive technology[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 215-219.
[6] E. Kadour-Peero, S. Khoury, J. Awad, L. Shpritz, L. Chen-Konak, C. Shechner, L. Saiegh. Determination of estradiol and progesterone concentrations in human scalp hair[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 268-271.
[7] S. J. Knight, A. D. Smith, H. Kim, A. C. Collier. Human placental suppressors of cytokine signalling (SOCS) and inflammatory cytokines are dysregulated in assisted reproduction, advanced maternal age and pre-term birth[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 277-286.
[8] M. Minase, T. Miyamoto, N. Hayashi, G. Minase, K. Nishiwaki, K. Sengoku. A patient with a didelphys vaginal septum and infertility diagnosed by laparoscopy and magnetic resonance imaging[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 988-989.
[9] I. Korkontzelos, A. Vlachioti, P. Mavridou, A. Rapi, G. Tsanadis, T. Stefos. Heterotopic triplet pregnancy after in vitro fertilization and intracytoplasmatic sperm injection complicated with ovarian hyperstimulation syndrome single twin fetal demise and cervical incompetence: a successful obstetrical outcome[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 1007-1010.
[10] P. Bakas, M. Simopoulou, P. Panagopoulos, N. Salakos, Ch. Siristatidis. Luteal phase progesterone and estradiol concentrations and their relation to the outcome of IVF/ICSI cycles with controlled ovarian stimulation[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 727-730.
[11] J.H. Check, C. Dietterich, M. Lowney, V. Sapoznikov, R. Difilippo, J. Giangreco, K. Clarkson. Adjusting progesterone (P) dosage to compensate for a non-homogeneous hyperechogenic (HH) echo pattern three days after embryo transfer[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(3): 356-358.
[12] Turgut Aydin, Huseyin Aksoy, Ozge Idem Karadag, Ulku Aksoy, Elif Cinar. A comparative study on therapeutic outcomes and clinical implications of transvaginal and transabdominal guidance during embryo transfer[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(6): 823-827.
[13] M.M. Khadra, M.A. Freij, Z.A. Al-Mazaydeh, S.E. Al-Mashhrawi, B.O. Rahhal, S.S. Saleh, R.M. Kilani, L.H. Tahtamouni. Factors influencing successful pregnancy outcomes in IVF cycles among Jordanian infertile couples[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(6): 855-860.
[14] L.E. Prado Correia, B.C. de Almeida, E. Chada Baracat, I. Silva, J.M. Soares Júnior, C.E. Bonduki, M. Abi Haidar. Efficacy and effects of transdermal hormone therapy in postmenopausal women[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 735-740.
[15] J.H. Check. Intractable severe peri-ovulatory sneezing abrogated by injection of human chorionic gonadotropin[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 781-781.
No Suggested Reading articles found!