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Clinical and Experimental Obstetrics & Gynecology  2020, Vol. 47 Issue (6): 821-828    DOI: 10.31083/j.ceog.2020.06.5387
Systematic Review Previous articles | Next articles
Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials
Y. Sun1, X. Chen1, X. Yuan1, L. Xu1, Y.C. Jin1, T.H. Ji1, X.L. Wang1, H.H. Dai1, *(), W.J. Cheng1, *()
1Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China
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Abstract  
Background: The aim of this meta-analysis was to compare levonorgestrel intrauterine system (LNG-IUS) with oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection. Materials and Methods: Computerized literature search was performed in PubMed and several Chinese databases to screen for relevant trials. Quality assessment and meta-analysis were performed for the included trials. Results: A total of 19 randomized controlled trials were identified. Meta-analysis indicated that the LNG-IUS group was associated with lower recurrence rate of endometrial polyps than the oral progestin group (p < 0.0001), while there was no significant difference in the incidence of abnormal uterine bleeding between groups (p > 0.05). In terms of adverse effects related to progestin, the LNG-IUS group had significantly fewer adverse effects than the oral progestin group (p < 0.0001). Additionally, the LNG-IUS group had thinner endometrium and higher hemoglobin levels than the oral progestin group (p < 0.00001). Conclusion: The LNG-IUS was more effective and safer in preventing the recurrence of endometrial polyps after hysteroscopic resection than oral progestin.
Key words:  Endometrial polyps      Levonorgestrel intrauterine system      LNG-IUS      Oral progestin      Meta-analysis     
Submitted:  13 September 2019      Accepted:  28 May 2020      Published:  15 December 2020     
Fund: 
2013, H201404, FRC201755/Research project of maternal and child health care in Jiangsu Province of China
81472442/the National Natural Science Foundation
*Corresponding Author(s):  daihuihua65@163.com (HUIHUA DAI); chengwenjundoc@163.com (WENJUN CHENG)   

Cite this article: 

Y. Sun, X. Chen, X. Yuan, L. Xu, Y.C. Jin, T.H. Ji, X.L. Wang, H.H. Dai, W.J. Cheng. Levonorgestrel intrauterine system versus oral progestin for preventing the recurrence of endometrial polyps after hysteroscopic resection: A meta-analysis of 19 randomized controlled trials. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 821-828.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog.2020.06.5387     OR     https://ceog.imrpress.com/EN/Y2020/V47/I6/821

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