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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 805-811    DOI: 10.12891/ceog4726.2019
Original Research Previous articles | Next articles
Pregnancy outcomes in patients with Marfan syndrome
Lan Bu1, †, Puyu Yang1, †, Jun Zhang1, *(), Yanna Li1, Jun Zheng2
1Department of Obstetrics and Gynecology, Medical Center of Severe Cardiovascular of Beijing Anzhen Hospital, Beijing, China
2Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Beijing, China
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Abstract  

Objective: The aims of this study were to evaluate the clinical characteristics of pregnant patients with Marfan syndrome and the maternal and fetal outcomes. Materials and Methods: Twelve pregnant women with Marfan syndrome were identified, who were treated in Beijing Anzhen Hospital Affiliated to Capital Medical University between January 2012 and May 2016. Results: Among 12 patients, six cases were diagnosed as type A aortic dissection, four cases were diagnosed as type B aortic dissection, one case had aortic dissection surgery before pregnancy, and one case was diagnosed with expansion of aortic sinus. Among the 12 cases, except for one patient with cardiac tamponade leading to heart failure, the remaining 11 cases had no complications. Six cases of newborns had a birth body mass between 1,080 to 3,500 grams; one case died after 14 days and five cases of newborns were alive without exception. Conclusion: Aortic dissection poses a serious risk for pregnant women with Marfan syndrome and the fetus, and the mortality rates for both the mother and the fetus are high. Early diagnosis and appropriate treatment should be based on maternal and fetal conditions. A multi-disciplinary team between obstetric and cardiovascular surgery is crucial in the outcome of these critical patients.

Key words:  Marfan syndrome      Pregnancy outcome      Cardiac surgical procedure      Extracorporeal circulation     
Published:  10 October 2019     
*Corresponding Author(s):  JUN ZHANG     E-mail:  zhangjundoc@126.com
About author:  Contributed equally.

Cite this article: 

Lan Bu, Puyu Yang, Jun Zhang, Yanna Li, Jun Zheng. Pregnancy outcomes in patients with Marfan syndrome. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 805-811.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4726.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I5/805

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