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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 792-796    DOI: 10.12891/ceog4974.2019
Original Research Previous articles | Next articles
Histological pattern of leiomyomas after ulipristal acetate treatment in women: a case-control study
E. Fila1, U. Indraccolo2, *(), M. Pedriali3, G. Scutiero2, C. Borghi2, P. Greco1
1Department of Morphology, Surgery and Experimental Medicine, Section of Obstetric and Gynaecology, University of Ferrara, Ferrara, Italy
2Maternal-Infantile Department. Section of Obstetrics and Gynecology. Sant'Anna University Hospital of Ferrara, Cona, Italy
3Department of Surgical Pathology, Sant'Anna University Hospital of Ferrara, Cona, Italy
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Abstract  

Purpose of Investigation: Assessing cytological and extracellular matrix histological patterns of uterine leiomyomas, in women previously treated with ulipristal acetate (UPA). Materials and Methods: Patients underwent surgical intervention for uterine leiomyomas between 2017 and 2018 were screened for previous use of UPA and were considered as cases. Controls were matched for race and nonmenopausal status among patients with surgeries for leiomyomas. Fibrosis, hyalinosis, edema, necrosis, cellularity, phlogosis, and mitosis were assessed in the specimens of fibroids by a semiquantitative score. The rates of scores for each histological pattern were compared among cases and controls, and described in a two-dimensional correspondence analysis. Results: There is not significance among scores between cases and controls fibroids, except than for the hyalinosis of moderate grade, that seems more likely in the ulipristal acetate group. The fibroids after ulipristals appear to have less mitosis and cellularity, while it seems to have more hyalinosis, edema and, in case of two cycles of ulipristal, fibrosis. Conclusions: Histological changes of leiomyomas after UPA therapy are heterogeneous. UPA mostly acts on extracellular matrix and, to a lesser extent, on histological parameters of smooth muscle cell proliferation.

Key words:  Leiomyomas      Ulipristal acetate      Fibroids      Extracellular matrix      Histological pattern     
Published:  10 October 2019     
*Corresponding Author(s):  U. INDRACCOLO     E-mail:  ugo.indraccolo@libero.it

Cite this article: 

E. Fila, U. Indraccolo, M. Pedriali, G. Scutiero, C. Borghi, P. Greco. Histological pattern of leiomyomas after ulipristal acetate treatment in women: a case-control study. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 792-796.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4974.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I5/792

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