Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (5): 784-786    DOI: 10.12891/ceog4840.2019
Original Research Previous articles | Next articles
Do bone turnover markers change with a steep drop in maternal steroids?
H.A. Mansouri1, *()
1King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia
Download:  PDF(361KB)  ( 182 ) Full text   ( 6 )
Export:  BibTeX | EndNote (RIS)      
Abstract  

Objectives: To study the changes of bone physiology during last trimester and compare it with immediate postpartum period associated with the sharp drop of pregnancy steroids. Introduction: The maximum transport of calcium and phosphate is at 36 weeks. The sudden drop of sex steroids after delivery could probably lead to a significant change in bone turnover markers. This study was performed to demonstrate if this has an impact on bone turnover markers (BTM). Materials and Methods: Women with a singleton non-complicated pregnancy were recruited from July 29, 2010 for two months to the end of September 2010. A serum level of bone profile, 25 OH vitamin D, and BTM was taken at 35-36 weeks and repeated at postpartum. A paired t-test using SPSS 16 was used to compare the means. Results: Serum bone profile values were comparable between the two groups. Although the mean postpartum serum value of 25-Oh vitamin (28.06 nmol/L) was lower than during pregnancy (35.72 nmol), it did not reach a statistical significance, in this population. A trend of increase in serum osteocalcin postpartum was observed (p = 0.05). Conclusions: This group of women had a high prevalence of vitamin D deficiency; this was not accompanied with changes in BTM; this suggests that a change in the level of steroids play a role that modify the expected interaction between vitamin D and BTM. Larger studies are however needed.

Key words:  Bone mineral density      Sex steroids      Vitamin D      Bone turnover markers     
Published:  10 October 2019     
*Corresponding Author(s):  H.A. MANSOURI     E-mail:  hamansouri@yahoo.com

Cite this article: 

H.A. Mansouri. Do bone turnover markers change with a steep drop in maternal steroids?. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 784-786.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4840.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I5/784

[1] Serdar Balci. The effect of ultraviolet index measurements on levels of vitamin D andinflammatory markers in pregnant women[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 888-892.
[2] R. Tachibana, H. Matsushita, A. Minami, N. Morita, S. Shimizu, H. Kanazawa, T. Suzuki, K. Watanabe, A. Wakatsuki. Dietary sesame diminishes bone mass and bone formation indices in ovariectomized rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 546-551.
[3] F. N. Tuysuzoglu, G. A. Ilhan, B. Yildizhan. The impact of surgical menopause on metabolic syndrome, bone mineral density, and vasomotor symptoms[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 179-182.
[4] A. M. Maysara, A. T. Nassar, H. K. Jubran. The effect of correction of serum level of vitamin D on hyperandrogenism in women with polycystic ovary syndrome and hypovitaminosis D[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(2): 272-276.
[5] A. Kalok, N.H.A. Aziz, D.A. Malik, S.A. Shah, D.N. Nasuruddin, M.H. Omar, N.A.M. Ismail, M.N. Shafiee. Maternal serum vitamin D and spontaneous preterm birth[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 16-20.
[6] N. Morita, H. Matsushita, A. Minami, S. Shimizu, R. Tachibana, H. Kanazawa, T. Suzuki, K. Watanabe, A. Wakatsuki. Effect of the methanol extract of the Lion’s Mane mushroom, Hericium erinaceus, on bone metabolism in ovariectomized rats[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(1): 47-52.
[7] H.-H. Lee, M.-J. Mun, T.-H. Kim, Y.-S. Kim, W.-C. Jang, J.-Y. Hwang. Relationships between vitamin D receptor genetic polymorphisms and endometriosis in Korean women[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(6): 876-880.
[8] M. Paliga, S. Horák. Relationship between endometriosis and vitamin D status - a review[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 674-678.
[9] Chunjuan Shen, Liping Wang, Xiaojie Wu, Shuhui Mao, Chunxia Fang. The relationship between vitamin D and IVF: a systematic review and meta-analysis[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 12-15.
[10] Burcin Karamustafaoglu Balci, Bulent Ergun. Prevalence of low vitamin D levels in infertile patients - a single center pilot study[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 104-107.
[11] Jung Yeob Seoung, Suk Woo Lee, Young Mo Kang, Min Jung Kim, Jae Min Park, Hye Min Moon, Chae Chun Rhim. Association between metabolic risks and bone mineral density in postmenopausal women[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 671-676.
[12] B. Dullaert, S. Schroven, Y. Jacquemyn. The effect of maternal vitamin D status on pregnancy outcome and child health in the first year of life[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 677-681.
[13] I. Soytac Inancli, E. Yayci, T. Atacag, M. Uncu. Is maternal Vitamin D associated with gestational diabetes mellitus in pregnant women in Cyprus?[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(6): 840-843.
[14] G. Özakşit, A. Tokmak, H. Kalkan, E. Sarıkaya. Is there an association between serum vitamin D levels and endometrial polyps?[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(4): 539-543.
[15] S. Yilmaz, A. Aktulay, C. Demirtas, Y. Engin-Ustun. Low cord blood serum levels of vitamin D: cause or effect of fetal macrosomia?[J]. Clinical and Experimental Obstetrics & Gynecology, 2015, 42(4): 501-504.
No Suggested Reading articles found!