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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (4): 641-645    DOI: 10.12891/ceog4733.2019
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The relationship between vaginal cavernous hemangiomas and late pregnancy. A case report and a review of the literature
T. Yamashita1, N. Takayanagi1, M. Higashi1, S. Momose1, J. Tamaru1, *()
1Department of Pathology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Saitama, Japan
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Abstract  

The occurrence of cavernous hemangiomas in the vagina is very rare. A 34-year-old woman at 33 weeks’ gestation was admitted with a large reddish mass of approximately 5 cm in diameter in the vagina, with bleeding and a sensation of discomfort with walking. The vaginal mass was excised to confirm the pathological diagnosis. Histopathological analysis showed various dilated vessels lined by increased endothelial cells, and the final diagnosis was vaginal cavernous hemangioma. The immunohistochemical analysis showed positive expressions of vascular endothelial growth factor (VEGF), estrogen receptor (ER), and progesterone receptor (PgR) in perivascular stromal cells around the hemangioma. Additionally, the authors reviewed the relationship between genital hemangiomas and pregnancy from the literature. In the female genital tract, six (75%) of eight vaginal hemangiomas were associated with pregnancy, in particular, late pregnancy, in addition to the present case, and eight (32%) of 25 cervical hemangiomas were seen in late pregnancy. Taken together, the hormonal status in late pregnancy may affect the formation of vaginal hemangiomas.

Key words:  Vagina      Hemangioma      Hormonal status      Pregnancy     
Published:  10 August 2019     
*Corresponding Author(s):  J. TAMARU     E-mail:  jtamaru@saitama-med.ac.jp

Cite this article: 

T. Yamashita, N. Takayanagi, M. Higashi, S. Momose, J. Tamaru. The relationship between vaginal cavernous hemangiomas and late pregnancy. A case report and a review of the literature. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(4): 641-645.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4733.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I4/641

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