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Clinical and Experimental Obstetrics & Gynecology  2019, Vol. 46 Issue (2): 320-322    DOI: 10.12891/ceog4599.2019
Case Report Previous articles | Next articles
The course and outcome of pregnancy in patient with concomitant Gilbert syndrome and hereditary spherocytosis: a unique case report
G. Bapayeva1, M. Terzic1, 2, 3, *(), K. Togyzbayeva1, A. Bekenova2, S. Terzic2
1National Research Center of Mother and Child Health, University Medical Center, Astana, Kazakhstan
2Department of Medicine, Nazarbayev University, School of Medicine, Astana, Kazakhstan
3Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburg School of Medicine, Pittsburg, Pennsylvania, USA
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Abstract  

Gilbert syndrome (GS) is an autosomal dominant mild unconjugated hyperbilirubinemia. Hereditary spherocytosis (HS) is an inherited condition of non-immune heterogeneous hemolytic anemia. These two diseases can be very rarely diagnosed in one patient, but there is not one case reported in pregnant patient. The authors present a unique case of concomitant both diseases in pregnancy. The patient was 25-years-old, conceived spontaneously, and carefully observed throughout the pregnancy. Considering that both diseases might have a detrimental influence on pregnancy course and outcome, especially in this case with severe form of HS, the woman was hospitalized and carefully observed until the end of pregnancy. She delivered vaginally without any feto-maternal complications. In conclusion, coexisting GS and HS during pregnancy deserve careful monitoring and up-to-date treatment. This case report shows that a contemporary approach to the pregnant patient with GS and HS can result in the delivery of a healthy baby without any complications.

Key words:  Gilbert syndrome      Hereditary spherocytosis      Pregnancy outcome      High-risk pregnancy     
Published:  10 April 2019     
*Corresponding Author(s):  M. TERZIC     E-mail:  terzicmilan@yahoo.co.uk

Cite this article: 

G. Bapayeva, M. Terzic, K. Togyzbayeva, A. Bekenova, S. Terzic. The course and outcome of pregnancy in patient with concomitant Gilbert syndrome and hereditary spherocytosis: a unique case report. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 320-322.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4599.2019     OR     https://ceog.imrpress.com/EN/Y2019/V46/I2/320

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