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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (5): 699-701    DOI: 10.12891/ceog4566.2018
Original Research Previous articles | Next articles
Intravenous Immunoglobulin (IVIg) for unexplained infertility: a case series
G. Genest1, *(), B. Elliott2, K. Spitzer3, C. A. Laskin4, W. Buckett5, L. Lapensée6, 7, I.J, Kadoch6, 7, P. Gol1
1 Department of Immunology, Montreal General Hospital, McGill University, Montreal, Canada
2 McGill University, Montreal, Canada
3 Trio Fertility, Toronto, ON, Canada
4 Department of Medicine and Obstetrics, University of Toronto, Toronto, Canada
5 Reproductive Centre, McGill University, Montreal, Canada
6 Department of Obstetrics and Gynecology, University of Montreal, Montreal, Canada
7 Department of Reproductive Medicine, Ovo Clinic, Montreal, Canada
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Abstract  
Intravenous Immunoglobulin (IVIg) is a potential treatment for immune mediated reproductive failure (IMRF), but its role in infertility treatments remains controversial. There is evidence that administering IVIg before conception improves pregnancy outcomes. In the present cohort, 13/15 (86%) patients had a live birth after receiving pre-conceptual IVIg at immunomodulatory doses. No serious maternal or fetal side effects directly attributable to IVIg were reported. The present results support the need for a randomized controlled trial (RCT) with this protocol.
Key words:  Immunology      Infertility      Maternal-fetal medicine     
Published:  10 October 2018     
*Corresponding Author(s):  G. GENEST     E-mail:  genevieve.genest@mail.mcgill.ca

Cite this article: 

G. Genest, B. Elliott, K. Spitzer, C. A. Laskin, W. Buckett, L. Lapensée, I.J, Kadoch, P. Gol. Intravenous Immunoglobulin (IVIg) for unexplained infertility: a case series. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 699-701.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4566.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I5/699

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