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Clinical and Experimental Obstetrics & Gynecology  2018, Vol. 45 Issue (4): 558-562    DOI: 10.12891/ceog4189.2018
Original Research Previous articles | Next articles
Downregulated osteopontin in placenta affects MMPs expression of trophoblastic cells
Manchao Li1, †, Baozhi Wang2, †, Zhiming He3, Yi Zhou3, Qun Fang3, *()
1 Reproductive Medicine Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2 General Surgery Department, The Fourth Affiliated Hospital of Gangzhou Medical University, Guangzhou, China
3 Fatal Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Abstract  
Trophoblastic invasion plays a critical role in placental development. Shallow of invasion could cause the abnormal placentation which may probably resulted in preeclampsia (PE). Extracellular matrix (ECM) proteins are confirmed to mediate cell adhesion, migration, and invasion. Osteopontin (OPN) is a kind of ECM protein and has been found to be involved in invasion and metastasis of several types of cancers. The authors hypothesize that OPN could probably regulate trophoblastic cell invasion. Here, the results showed that the expression level of OPN significantly decreased in the placenta of PE. Furthermore the authors found that OPN-siRNA interference significantly decreased the expression of MMP-2, MMP-9 in villous explant, a crucial signaling molecule of trophoblast invasion. The findings suggest that OPN is a critical ECM protein for regulating trophoblastic cell invasion.
Key words:  Osteopontin      Trophoblast      Invasion      Villous explant     
Published:  10 August 2018     
*Corresponding Author(s):  QUN FANG     E-mail:  fang_qun@163.com
About author:  † Contributed equally.

Cite this article: 

Manchao Li, Baozhi Wang, Zhiming He, Yi Zhou, Qun Fang. Downregulated osteopontin in placenta affects MMPs expression of trophoblastic cells. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(4): 558-562.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog4189.2018     OR     https://ceog.imrpress.com/EN/Y2018/V45/I4/558

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[2] E.H. Comert, H. Sal, E.S. Guvendag Guven, S. Guven. Pulmonary lymphangioleiomyomatosis as an uncommon cause of recurrent early pregnancy loss[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(5): 831-832.
[3] G.-Y. Xia, Q.-Q. Fu, H.-M. Li, M. Fang, T. Zhang, M.-W. Wu, L.-M. Chen, C.-Y. Wu, B. Yu, H.-T. Pan, X.-L. Shi. Downregulation of Hsp27 inhibits proliferation, migration and invasion in human choriocarcinoma cell line JAR[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(2): 245-249.
[4] C.E. Bedient, D. Rodriguez, N. Sidell, C. Roberts, S.C. Schutte. Alterations in the invasive properties of peripheral blood monocytes from patients with endometriosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2019, 46(1): 60-65.
[5] Yi Wu, Weidong Dai, Qiaoshan Fu. Increased apoptosis of trophoblasts from pregnancies complicated by intrauterine growth restriction is associated with aberrant Fas-associated death domain (FADD) expression[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(5): 747-751.
[6] N. Mchunu, P. Pillay, J. Moodley, I. Mackraj. Circulatory levels of tumor necrosis factor-α, interleukin-6, and syncytiotrophoblast microvesicles in the first trimester of pregnancy[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(4): 575-581.
[7] Xiaohua Song, Dianzhong Geng, Jian Li, Lei Yan, Zi-Jiang Chen. Fertility preservation of PSTT by interventional therapy: a case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2018, 45(4): 608-611.
[8] T. Tsunemi, T. Sado, K. Naruse, H. Kobayashi. Paternal contribution to the preeclampsia phenotype[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 914-922.
[9] E. Rodriguez, J.O. Zamora, I.R. Monfort, L. Rubert, S. Fuster, V. Diago, A. Perales. Unusual twin pregnancy: complete hydatidiform mole with coexistent normal fetus[J]. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(3): 492-493.
[10] J. H. Check, J. Aly, E. Chang. Improving the chance of successful implantation – part I – embryo attachment to the endometrium and adequate trophoblast invasion[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(6): 787-791.
[11] A. Liberis, G. Stanulov, E. Chafouz Ali, A. Hassan, A. Pagalos, E.N. Kontomanolis. Pre-eclampsia and the vascular endothelial growth factor: a new aspect[J]. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(1): 9-13.
[12] A. Kondi-Pafiti, C. Grigoriadis, D. Samiotaki, A. Filippidou-Giannopoulou,C. Kleanthis, D. Hassiakos. Immunohistochemical study of Inhibin A and B expression in placentas from normal and pathological gestations[J]. Clinical and Experimental Obstetrics & Gynecology, 2013, 40(1): 109-112.
[13] O. Akbayır, I. Alkis, A. Corbacioglu, A. Ekiz, A. Akca, S. Cekic. Exaggerated placental site reaction detected during caesarean delivery: a case report[J]. Clinical and Experimental Obstetrics & Gynecology, 2012, 39(2): 234-235.
[14] S. Sotiriou, K. Liatsos, I. Ladopoulos, D. L. Arvanitis. A comparison in concentration of heat shock proteins (HSP) 70 and 90 on chorionic villi of human placenta in normal pregnancies and in missed miscarriages[J]. Clinical and Experimental Obstetrics & Gynecology, 2004, 31(3): 185-190.
[15] R. Gaetje, D. W. Winnekendonk, A. Ahr, M. Kaufmann. Ovarian cancer antigen CA 125 influences adhesion of human and mammalian cell lines in vitro[J]. Clinical and Experimental Obstetrics & Gynecology, 2002, 29(1): 34-36.
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