Please wait a minute...
Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (6): 870-874    DOI: 10.12891/ceog3668.2017
Original Research Previous articles | Next articles
Clinical investigation of congenital heart defects in prenatal life: a retrospective study on 198 cases
Q.C. Wu1, *(), W.B. Wang1, L.K. Zheng1, L. Sun1, X.H. Zhong1, Y.S. Xu1, X.J. Xie1, Z.Y. Su1
1 Prenatal Diagnosis Center of Xiamen’s Maternal & Child Health Care Hospital, Xiamen City, China
Download:  PDF
Export:  BibTeX | EndNote (RIS)      
Abstract  
Objective: The authors present a necropsy study of fetal congenital heart defects (CHD) collected retrospectively, to investigate the spectrum of CHD in prenatal life and the frequency of extracardiac malformations and the proportion of chromosome abnormalities among the fetuses. Materials and Methods: During a five-year period, necropsies were performed in 198 fetuses with congenital heart anomalies identified by prenatal ultrasound and for which prenatal cytogenetic analyses were performed on fetal cells obtained by amniocentesis and cordocentesis. Sequential segmental analysis was used to describe cardiac defects according to the prenatal ultrasound findings and postnatal necropsy results. The classification of these cases was referred to the grading suggested by Choi. Results: The 198 cases were divided into two groups: group 1 described fetuses with severe cardiac anomalies which contained 90 cases and group 2 described fetuses with complex cardiac anomalies which contained 108 cases. In the spectrum of heart malformations, complex cardiac anomalies comprised 54.5% of the malformations and severe cardiac anomalies comprised 45.5% in the present necropsy population. Extracardiac malformations accounted for 104 cases (52.5%), and chromosome abnormalities were diagnosed in 34 fetuses (17.2%). Conclusion: Fetal cardiac anomalies detected in the present study were more severe than those in previous cardiology surveys. The present data will provide an adequate basis for future genetic counseling and improvement of prenatal care for fetal congenital heart defects.
Key words:  Congenital heart defects      Extracardiac malformations      Chromosomal abnormalities      Necropsy      Ultrasound     
Published:  10 December 2017     
*Corresponding Author(s):  Q.C. WU     E-mail:  qichang_wu@163.com

Cite this article: 

Q.C. Wu, W.B. Wang, L.K. Zheng, L. Sun, X.H. Zhong, Y.S. Xu, X.J. Xie, Z.Y. Su. Clinical investigation of congenital heart defects in prenatal life: a retrospective study on 198 cases. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(6): 870-874.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3668.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I6/870

[1] Christina M. Moisidis-Tesch, Nicole Vedder, Norman A. Ginsberg. Rapid rate of growth in adnexal masses, despite benign appearance on ultrasound, was associated with malignancy. A retrospective analysis of 48 consecutive cases from a single institution[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1081-1088.
[2] Ryuichi Shimaoka, Tomomi Shiga, Ken-ichirou Morishige. Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1126-1131.
[3] Mahmoud Alalfy, Soha Talaat Hamed, Alaa Sobhi Abd El Ghani, Ahmed Elgazzar, Amr Abbassy, Ahmed S. S. A. Rashwan, Omar Nagy, Mohamed A Shalaby, Hatem Hassan, Asmaa Ibrahem, Hesham Kamal, Reham Mahrous, Eman Kamal. The accuracy of 3D-TUI and 3D power Doppler using Alalfy simple criteria in the diagnosis of placenta accreta spectrum[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1132-1140.
[4] Ji-Chen Wang, De-Ying Wei, Chen Su, Qi Han, Yong-Hao Gai. Intraoperative management of a Robert's uterus without hematometra in blind hemi-cavity preoperatively misdiagnosed as septate uterus[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1219-1223.
[5] Maria Aparecida Mazzutti Verlangieri Carmo, Helmer Herren, Francisco J. C. Dos-Reis, Fabricio Da Silva Costa, Julio C. Rosa-e-Silva, Antonio Alberto Nogueira, Omero Benedicto Poli-Neto. Reliability and agreement of three-dimensional/four-dimensional transperineal ultrasound in women with chronic pelvic pain[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 494-499.
[6] Lejla Kamerić, Anis Cerovac, Mirzeta Rizvanović, Alen Kamerić, Mahira Jahić, Dubravko Habek. Frequency of cesarean section in pregnant women with risk factors for preeclampsia: prospective cohort study[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 561-566.
[7] Özgür Koçak, Cem Koçak. Finding the best formulas to estimate fetal weight based on ultrasound for the Turkish population: a comparison of 24 formulas[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 676-685.
[8] Angel Yordanov, Krasimira Zhelyaskova. Prenatal ultrasonographic diagnosis of fetal scrotal inguinal hernia: a case report and literature review[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 723-727.
[9] Ryuichi Shimaoka, Tomomi Shiga, Ken-ichirou Morishige. Change in uterine artery blood flow with intrauterine balloon tamponade[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 307-311.
[10] Jun Wang, Xiao-Dong Zhao, Gang Wang, Wei-Ming Li, Hua Guo, Jia-Mei Gou, Guo-Juan Feng, Jing Rao. The accuracy of pulmonary ultrasound in the diagnosis and monitoring of community-acquired pneumonia in women of childbearing age[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 381-388.
[11] Rui-Ke Liu, Li Li, Xue-Qian Du, Ying Wang, Shuai Chen, Gui-Lian Li, Gui-Fang Li. Gestational age affects the cerebellum development in neonatal infants: establishment of cerebellar extrauterine reference values as a function of gestational age[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 395-401.
[12] Suchaya Luewan, Pakorn Chaksuwat, Tip Pongsuvareeyakul, Theera Tongsong. Prenatal sonographic findings and management of placental mesenchymal dysplasia[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(2): 439-443.
[13] Duygu Adıyaman, Bahar Konuralp Atakul, Melda Kuyucu, Hakan Gölbasi, Atalay Ekin. Difference between near-field and far-field of middle cerebral artery doppler pulsatility index and peak systolic velocity: a prospective study[J]. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(1): 66-72.
[14] Shuhao Deng, Yicheng Zhu, Quan Jiang, Yuan Zhang. Evaluation of four-dimensional ultrasound for diagnosis of female pelvic floor dysfunction and prognosis[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(6): 950-954.
[15] C. Stenfelt, L. Ydenius, S. Lindberg, J. Spira, G. Edelstam. Effects of the colour and design of a new pelvic examination chair on comfort during gynaecological examination[J]. Clinical and Experimental Obstetrics & Gynecology, 2020, 47(4): 556-559.
No Suggested Reading articles found!