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Clinical and Experimental Obstetrics & Gynecology  2017, Vol. 44 Issue (5): 716-720    DOI: 10.12891/ceog3529.2017
Original Research Previous articles | Next articles
The association between cystatin C and metabolic syndrome according to menopausal status in healthy Korean women
Y.J. Lee1, K.Y. Yun1, S.C. Kim1, J.K. Joo1, *(), K.S. Lee1
1 Department of Obstetrics and Gynecology, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea
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Abstract  
Objective: Cystatin C (Cys-C) is used as a marker for the measurement of the glomerular filtration rate (GFR) in chronic kidney disease and as a predictive marker of cardiovascular disease. The authors investigated the relationship between serum Cys-C level and metabolic syndrome (MetS). Materials and Methods: A total of 3,670 women who visited the health promotion center were included in the cross-sectional study. Single logistic regression analysis was used to analyze the relationship between Cys-C and MetS in premenopausal and postmenopausal women. One-way analysis with linear trends was performed to determine the association between serum Cys-C level and MetS components. Results: The authors divided the subjects into four groups (premenopausal women with or without MetS, postmenopausal women with or without MetS) and compared the interquartile range (IQR) of the basic characteristics in each group. The level of Cys-C was increased only in postmenopausal women with MetS. The mean value of Cys-C increased progressively as the number of MetS components increased and the p value for the trend (p < 0.0001) was lower in postmenopausal women with MetS. Logistic regression analysis showed that the mean value of Cys-C was higher in MetS women and that the odds ratio was higher in postmenopausal women with MetS than in premenopausal women with MetS. These results indicated that the interaction between Cys-C and MetS was higher in postmenopausal women with MetS. Conclusions: Higher Cys-C level was found to have a positive correlation with MetS in Korean premenopausal and postmenopausal women. These interactions were more significant in postmenopausal women.
Key words:  Cystatin C      Menopause      Metabolic syndrome     
Published:  10 October 2017     
*Corresponding Author(s):  J.K. JOO     E-mail:  jkjoo@pusan.ac.kr

Cite this article: 

Y.J. Lee, K.Y. Yun, S.C. Kim, J.K. Joo, K.S. Lee. The association between cystatin C and metabolic syndrome according to menopausal status in healthy Korean women. Clinical and Experimental Obstetrics & Gynecology, 2017, 44(5): 716-720.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3529.2017     OR     https://ceog.imrpress.com/EN/Y2017/V44/I5/716

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