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Clinical and Experimental Obstetrics & Gynecology  2016, Vol. 43 Issue (6): 812-817    DOI: 10.12891/ceog3147.2016
Original Research Previous articles | Next articles
Clinico-biochemical characteristics of 229 Portuguese infertile women with polycystic ovary syndrome: clinical relevance and relationship with fertility treatment results
P. Marques1, *(), F. Ferreira2, A. P. Soares3, J. Nunes3, S. Sousa3, A. Aguiar3, C. Calhaz-Jorge3
1Department of Endocrinology, Portuguese Institute of Oncology, Lisbon
2Department of Endocrinology, Hospital Santa Maria, CHLN, Lisbon
3Department of Obstetrics and Gynecology, Reproductive Medicine Unit, Hospital Santa Maria, Lisbon (Portugal)
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Abstract  
Purpose: Polycystic ovary syndrome (PCOS) affects 6-20% of reproductive-age women. The authors aimed to evaluate the characteristics of PCOS women and its relationship with fertility treatment outcomes. Materials and Methods: The authors reviewed records of PCOS women assisted at Hospital Santa Maria. Fertility treatment results were assessed as pregnancy rate, number of cycles, and miscarriage rate. Results: They identified 229 PCOS women, 179 (78.2%) had waist circumference > 80 cm, 72 (31.4%) had type 2 diabetes mellitus (T2DM) familial history and glucose abnormalities, hypertriglyceridemia and low cholesterol-HDL were detected in 23(10.1%), 15 (6.6%) and 103 (45.0%), respectively. Pregnancy was achieved in 164 women. The mean number of cycles to achieve pregnancy was 2.7 (±2.2). Statistical analysis identified factors associated with longer/higher number of treatments: primary infertility, T2DM familial history, hypertriglyceridemia, and low cholesterol-HDL. Waist circumference > 80 cm, older age, and increased LH level were associated with miscarriage. Conclusions: Primary infertility, T2DM familial history, hypertriglyceridemia, low cholesterol-HDL, older age, waist circumference > 80 cm, and high LH may confer poorer fertility treatment results.
Key words:  Polycystic ovary syndrome      Infertility      Oligomenorrhea      Clinical pregnancy      Spontaneous abortion     
Published:  10 December 2016     
*Corresponding Author(s):  P. MARQUES     E-mail:  pedro.miguel.sousa.marques@gmail.com

Cite this article: 

P. Marques, F. Ferreira, A. P. Soares, J. Nunes, S. Sousa, A. Aguiar, C. Calhaz-Jorge. Clinico-biochemical characteristics of 229 Portuguese infertile women with polycystic ovary syndrome: clinical relevance and relationship with fertility treatment results. Clinical and Experimental Obstetrics & Gynecology, 2016, 43(6): 812-817.

URL: 

https://ceog.imrpress.com/EN/10.12891/ceog3147.2016     OR     https://ceog.imrpress.com/EN/Y2016/V43/I6/812

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