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Clinical and Experimental Obstetrics & Gynecology  2008, Vol. 35 Issue (3): 221-224    DOI:
Case Report Previous articles | Next articles
Partial placenta increta and methotrexate therapy: three case reports
S. Pinho1, *(), S. Sarzedas1, S. Pedroso1, A. Santos1, M. Rebordão1, T. Avillez1, E. Casal1, M. Hermida1
1Department of Obstetrics, Garcia de Orta Hospital, Almada (Portugal)
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Abstract  
The term placenta accreta is used to describe any placental implantation in which there is abnormally firm adherence to the uterine wall. This condition complicates 1/2,500 deliveries and is rising in incidence. Abnormal placentation is associated with increased maternal morbidity and mortality from severe hemorrhage, uterine perforation, infection and loss of fertility. The reported experience of methotrexate treatment in the conservative management of placenta accreta is scant. Three cases of partial placenta increta managed with methotrexate are described. The patients were assessed with clinical surveillance, serum β human chorionic gonadotrophin (β-hCG) and imaging (ultrasonography and magnetic resonance in one case). In all cases conservative management with methotrexate resulted in undetectable serum β-hCG, a decrease in the size of partial placenta retained, and undetectable vascularization.
Key words:  Placenta accreta      Conservative management      Methotrexate     
Published:  10 September 2008     
*Corresponding Author(s):  S. PINHO     E-mail:  s.pinho@netcabo.pt

Cite this article: 

S. Pinho, S. Sarzedas, S. Pedroso, A. Santos, M. Rebordão, T. Avillez, E. Casal, M. Hermida. Partial placenta increta and methotrexate therapy: three case reports. Clinical and Experimental Obstetrics & Gynecology, 2008, 35(3): 221-224.

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https://ceog.imrpress.com/EN/     OR     https://ceog.imrpress.com/EN/Y2008/V35/I3/221

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