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Clinical and Experimental Obstetrics & Gynecology  2008, Vol. 35 Issue (3): 198-201    DOI:
Original Research Previous articles | Next articles
The effect of buserelin acetate on the uterus of adult rats: morphological aspects
C. R. Trindade1, *(), A. F. Camargos2, F. E. L. Pereira3
1Department of Gynecology and Obstetrics, School of Medicine, School of Health Sciences, Espírito Santo
2Department of Gynecology and Obstetrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais
3Department of Pathology, School of Medicine, Federal University of Espírito Santo, Espírito Santo (Brazil)
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Abstract  
Purpose of investigation: To evaluate the effect of buserelin acetate on the morphology of the endometrium of adult, non-castrated, female Wistar rats. Methods: Female Wistar rats at estrus or diestrus (assessed by vaginal cytology) received daily subcutaneous injections of 20 mg buserelin acetate for four, eight or 12 days. Rats were sacrificed 24 hours or five days following final dosage. A control group received diluent for 12 days. Results: Progressive tissue hypotrophy occurred during treatment and was followed by estrogenic hyperactivity five days after the end of treatment. Vaginal cytology and endometrial histology revealed intense, vacuolized lining and glandular epithelia, brush borders and endometrial stroma densely infiltrated with eosinophils. Conclusions: Buserelin acetate appears to cause a progressive blockade of gonadotrophin secretion when administered to female rats for four, eight or 12 days, and an important rebound effect, with accentuated estrogen release already apparent in the first estrous cycle following treatment.
Key words:  Buserelin      Gonadotrophin      Female rats      Estrous cycle      Cytology      Endometrium      Eosinophilia     
Published:  10 September 2008     
*Corresponding Author(s):  C. R. TRINDADE     E-mail:  celiart@terra.com.br

Cite this article: 

C. R. Trindade, A. F. Camargos, F. E. L. Pereira. The effect of buserelin acetate on the uterus of adult rats: morphological aspects. Clinical and Experimental Obstetrics & Gynecology, 2008, 35(3): 198-201.

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https://ceog.imrpress.com/EN/     OR     https://ceog.imrpress.com/EN/Y2008/V35/I3/198

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