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Clinical and Experimental Obstetrics & Gynecology  2008, Vol. 35 Issue (3): 172-174    DOI:
Original Research Previous articles | Next articles
Inherited thrombophilia screening in Greek women with recurrent fetal loss
A. Mougiou1, G. Androutsopoulos2, *(), M. Karakantza1, E. Theodori1, G. Decavalas2, N. Zoumbos1
1Department of Internal Medicine, Division of Hematology, 2Department of Obstetrics and Gynecology, University of Patras, Medical School, Rion (Greece)
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Abstract  
Objective: The present study was designed to determine the prevalence of factor V Leiden (FVL), prothrombin gene G20210A (PTG) and methylenetetrahydrofolate reductase (MTHFR C677T) mutations in women from South-Western Greece with recurrent fetal loss (RFL) and negative personal thromboembolic history. Materials and Methods: 212 women with RFL and 181 women with at least two pregnancies with normal outcome and no history of pregnancy loss were investigated for the commonest thrombophilic mutations (FVL, PTG, MTHFR C677T). Comparisons between groups were performed by Pearson’s chi-square test and odd ratios were calculated. Results: An abnormal genotype was detected in 49 women of the study group (23.1%) and in 41 women of the control group (22.6%). Conclusion: Inherited thrombophilia screening is not indicated as an initial approach in Greek women with RFL and negative personal thromboembolic history.
Key words:  First trimester recurrent fetal loss      Factor V Leiden      Prothrombin G20210A      MTHFR C677T      Molecular thrombophilic testing     
Published:  10 September 2008     
*Corresponding Author(s):  G. ANDROUTSOPOULOS     E-mail:  androutsopoulosgeorgios@hotmail.com

Cite this article: 

A. Mougiou, G. Androutsopoulos, M. Karakantza, E. Theodori, G. Decavalas, N. Zoumbos. Inherited thrombophilia screening in Greek women with recurrent fetal loss. Clinical and Experimental Obstetrics & Gynecology, 2008, 35(3): 172-174.

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https://ceog.imrpress.com/EN/     OR     https://ceog.imrpress.com/EN/Y2008/V35/I3/172

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