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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (5): 1224-1226    DOI: 10.31083/j.ceog4805195
Case Report Previous articles | Next articles
Retiform hemangioendothelioma of the vulva: a case report
Hai-Jiao Wang1, Zhi-Chen Ding1, Xu Yan2, Ying Yue1, *()
1Department of Gynecologic Oncology, First Hospital of Jilin University, 130021 Changchun, Jilin, China
2Department of Pathology, First Hospital of Jilin University, 130021 Changchun, Jilin, China
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Abstract  
Background: To report a rare case of retiform hemangioendothelioma (RH) originated from the vulva and review the relative references. Case: A 38-year-old woman was admitted to our hospital with a vulvar subcutaneous nodule (diameter about 2 cm) for 2 years. The clinical examination findings, laboratory test results, including complete blood count and liver function test results were normal. The B mode ultrasound revealed that a hypoechoic nodule with a clear boundary was observed on the right side of the vulva. The size was measured to be 23 mm × 8 mm. An expanded resection with the excision range extending 1 cm and the depth reaching the fascia was performed. The histologic examination revealed that the elongated, arborizing, thin-walled vessels were abundant on the tumor, the inner wall of the vessels was arranged with monolayer cells with uniform morphology. Local infiltration of lymphocyte has been found around the vessels. Immunohistochemical examinations showed that the endothelial cells were CD31, CD34 and friend leukemia virus integration 1 (Fli-1) positive, the smooth muscle actin (SMA) was scattered positive, further confirming the diagnosis of RH. The patient was followed up for 15 months, no local recurrence was found. Conclusions: Vulvar region is the rare affected region of RH, which is lack of characteristic findings in clinical examinations and laboratory tests. The pathology and immunohistochemistry are necessary for the diagnosis of vulvar RH. Local expanded resection of tumor may be an effective method for the treatment of early-stage RH to reduce the risk of local recurrence.
Key words:  Retiform hemangioendothelioma      RH      Vulva      CD31      CD34      Fli-1     
Submitted:  24 January 2021      Revised:  16 February 2021      Accepted:  24 February 2021      Published:  15 October 2021     
*Corresponding Author(s):  Ying Yue     E-mail:  yuey@jlu.edu.cn

Cite this article: 

Hai-Jiao Wang, Zhi-Chen Ding, Xu Yan, Ying Yue. Retiform hemangioendothelioma of the vulva: a case report. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1224-1226.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog4805195     OR     https://ceog.imrpress.com/EN/Y2021/V48/I5/1224

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