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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (5): 1126-1131    DOI: 10.31083/j.ceog4805181
Original Research Previous articles | Next articles
Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta
Ryuichi Shimaoka1, *(), Tomomi Shiga1, Ken-ichirou Morishige1
1Department of Obstetrics & Gynecology, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu-shi, Gifu-prefecture, 501-1194 Gifu, Japan
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Abstract  
Background: Adequate placental perfusion is important for fetal development and well-being, but the effect of tocolysis on placental perfusion is unclear. The aim of this study was to evaluate changes in fetal cardiac output distribution to the placenta following ritodrine tocolysis. Methods: This retrospective study involved 244 ultrasound findings in 142 singleton cases of appropriate for gestational age fetuses. The fetal cardiac output distribution to the placenta was defined and calculated as the percentage of umbilical vein flow volume (UVFV) based on the combined cardiac output (CCO). Ultrasound findings of 28 patients in the ritodrine group and 114 patients in the control group were compared using the unpaired t-test and Mann-Whitney U-test. Results: The CCO and UVFV increased as gestation progressed. On the other hand, distribution to the placenta was constant at approximately 15% from 28 to 35 weeks of gestation. Compared with the control group, the ritodrine group showed a significant increase in fetal heart rate, and the CCO also increased. The increase in UVFV in the ritodrine group was attributed to a significant increase in both the umbilical vessel diameter and blood flow velocity. As a result, distribution to the placenta in the ritodrine group was constant at about 20% and had a 5% increase at each week of gestation compared to the control group. Conclusions: To conclude, ritodrine tocolysis increased the fetal cardiac output distribution to the placenta. Additional research is required to determine whether tocolysis improves the placental perfusion in fetal growth restriction due to reduced placental perfusion.
Key words:  Distribution to the placenta      Doppler ultrasound      Fetal cardiac output      Ritodrine      Umbilical vein flow volume     
Submitted:  16 March 2021      Revised:  08 June 2021      Accepted:  28 June 2021      Published:  15 October 2021     
*Corresponding Author(s):  Ryuichi Shimaoka     E-mail:  ryuichi.shimaoka.official@gmail.com

Cite this article: 

Ryuichi Shimaoka, Tomomi Shiga, Ken-ichirou Morishige. Effect of ritodrine tocolysis on fetal cardiac output distribution to the placenta. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1126-1131.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog4805181     OR     https://ceog.imrpress.com/EN/Y2021/V48/I5/1126

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