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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (5): 1107-1110    DOI: 10.31083/j.ceog4805178
Original Research Previous articles | Next articles
The effect of follicular fluid-related hormones and vascular endothelial factor levels on the formation of high-quality embryos
Lin Liang1, Xiao Xi Zhao2, *()
1The Reproductive Center, Affiliate Hospital of Inner Mongolia Medical University, 010050 Hohhot, Inner Mongolia, China
2Department of Gynecology and Obstetrics, Affiliate Hospital of Inner Mongolia Medical University, 010050 Hohhot, Inner Mongolia, China
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Abstract  
Background: The purpose of this study was to investigate the possible influence of follicular fluid (FF)-related hormones and vascular endothelial factor (VEGF) levels on oocytes, and the resulting effect on formation of high-quality embryos, to provide a scientific basis for improving controlled ovarian stimulation. Methods: The levels of hormones and VEGF in FF were determined by performing enzyme-linked immunoassays. According to the number of high-quality embryos obtained, the patients were divided into three groups, and the levels and constitution of hormones and VEGF in FF were compared. Based on the results of correlation analysis, the number of oocytes harvested and the concentration of follicle-stimulating hormone (FSH) in FF were substituted into multiple logistic regression models. Results: The number of high-quality embryos was negatively correlated with FSH concentration (correlation coefficient = –0.305, p = 0.0001). The concentration of VEGF, FSH, luteinising hormone, and estradiol in FF was significantly different among the different high-quality embryo number groups. Multiple logistic regression results showed that the FSH concentration in the FF of the group without embryos was significantly higher than that of the other two groups, and the number of eggs obtained in the third group was significantly higher than that of the group without embryos. Conclusion: In the late stage of follicular development, FSH concentration in FF and the number of oocytes obtained affects the formation of high-quality embryos.
Key words:  Follicular fluid      Vascular endothelial growth factor      Hormones     
Submitted:  01 January 2021      Revised:  11 February 2021      Accepted:  23 March 2021      Published:  15 October 2021     
Fund: 
81660542/Natural Science Foundation of China
2018MS08091/Inner Mongolia Natural Science Fund
*Corresponding Author(s):  Xiao Xi Zhao     E-mail:  zhaoxx.3675@163.com

Cite this article: 

Lin Liang, Xiao Xi Zhao. The effect of follicular fluid-related hormones and vascular endothelial factor levels on the formation of high-quality embryos. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(5): 1107-1110.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog4805178     OR     https://ceog.imrpress.com/EN/Y2021/V48/I5/1107

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