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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (4): 969-973    DOI: 10.31083/j.ceog4804153
Original Research Previous articles | Next articles
The possible association of uterine fibroid formation with copper intrauterine device use: a cross-sectional study
Sevcan Arzu Arinkan1, *(), Hilal Serifoglu1
1Department of Obstetrics and Gynecology, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, 34668 Istanbul, Turkey
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Abstract  
Background: Fibroids are the most common pelvic tumors in females, affecting approximately 30%–50% of women of fertility age. Intrauterine devices (IUDs) are widely used in the world. Copper-IUDs which are one of the common causes of intrauterine chronic inflammation might create a suitable microenvironment for fibroid growth. This study aimed to find an answer to investigate whether there is an association between fibroids and copper (Cu) T-IUD use. Methods: This cross-sectional study was conducted with 788 participants. The participants were divided into two groups based on fibroid presence (study group) or absence (control group). For this study, usage of IUDs was defined as Cu T-IUD use for at least one year. Medical and obstetric history, oral contraceptive (OC) and/or IUD use and duration of use, as well as smoking, were questioned. Results: In participants who had fibroids, IUD use was found to be statistically significantly higher (55.5% vs 43.4%) (P = 0.001). In addition, according to multiple logistic regression analysis, having fibroids was found to be significantly related to age, number of abortions, smoking, and duration of Cu T-IUD use. A statistically significant correlation was not found between fibroid diameter, parity, and duration of OC use; however, a statistically weak correlation was found between fibroid size and duration of Cu T-IUD use. Conclusions: This study points to the association of Cu T-IUD use, inflammation, and fibroids. Our results can provide a steppingstone for the development of additional studies investigating this hypothesis. If inflammation is the preliminary event and copper IUDs cause inflammation, preventive health strategies may be implemented to lessen the possibility of fibroid development.
Key words:  Contraception      Etiology      Inflammation      Intrauterine device      Uterine fibroid      Leiomyoma     
Submitted:  29 January 2021      Revised:  14 April 2021      Accepted:  19 April 2021      Published:  15 August 2021     
*Corresponding Author(s):  Sevcan Arzu Arinkan     E-mail:  arzuarinkan@gmail.com

Cite this article: 

Sevcan Arzu Arinkan, Hilal Serifoglu. The possible association of uterine fibroid formation with copper intrauterine device use: a cross-sectional study. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 969-973.

URL: 

https://ceog.imrpress.com/EN/10.31083/j.ceog4804153     OR     https://ceog.imrpress.com/EN/Y2021/V48/I4/969

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