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Clinical and Experimental Obstetrics & Gynecology  2021, Vol. 48 Issue (4): 942-948    DOI: 10.31083/j.ceog4804149
Original Research Previous articles | Next articles
A retrospective series of homologous intracytoplasmic sperm injection cycle results of 99 women with mosaic Turner syndrome
Nur Dokuzeylul Gungor1, *(), Kagan Güngör2, Mustecep Kavrut3, Arzu Yurci4
1BAU Medical Park Göztepe Hospital Reproductive Endocrinology and IVF, 34815 Istanbul, Turkey
2Endocrinology and Metabolism, Istanbul Medeniyet University Goztepe Training and Research Hospital, 34363 Istanbul, Turkey
3Private Center, 34394 Istanbul, Turkey
4Gynecology and Obstetric, Memorial Kayseri Hospital IVF Center, 38110 Kayseri, Turkey
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Abstract  
Background: Although pregnancy is reported in both classical and mosaic forms of Turner syndrome (TS), both spontaneous and in-vitro-fertilisation (IVF) success rates were found higher in mosaic cases. In this study we analysed homologous intracytoplasmic sperm injection cycle results of infertile patients diagnosed with mosaic TS. Methods: Ninety nine female patients who had infertility complaints for 2 years or more and were diagnosed with mosaic TS were included in the study. They were treated according to a standard antagonist protocol. Embryo transfer was performed after pre-implantation genetic diagnosis (PGD) in 53 cases while embryo transfer was performed in remaining 46 cases without PGD. Results: While 45,X/46,XX karyotype was found in 55 of 99 cases, 45,X/46,XX/47,XXX karyotype was found in 32 cases. The remaining participants consisted of rare karyotype forms. The total number of patients conceived after the antagonist protocol was 31 (31.3%). While 18 of these cases resulted in term delivery (58%), the remaining 13 cases resulted in miscarriage (41.9%). Pregnancy could not be obtained in only 2 cases whose karyotype were 45,X/47,XXX and 45,X/46,XX/46,XY. Karyotype analysis was performed in only 2 of 18 newborn babies due to suspicious physical findings, but the results were reported as normal. Discussion: On the basis of our observations in this largest mosaic TS series, homologous IVF should be considered in infertile patients with Turner syndrome with high-grade mosaicism. PGD should also be recommended to TS patients on IVF treatment.
Key words:  Mosaic Turner syndrome      Homologous IVF      Antagonist protocol      PGD     
Submitted:  04 April 2021      Revised:  08 July 2021      Accepted:  09 July 2021      Published:  15 August 2021     
*Corresponding Author(s):  Nur Dokuzeylul Gungor     E-mail:  drnur9eylul@hotmail.com

Cite this article: 

Nur Dokuzeylul Gungor, Kagan Güngör, Mustecep Kavrut, Arzu Yurci. A retrospective series of homologous intracytoplasmic sperm injection cycle results of 99 women with mosaic Turner syndrome. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(4): 942-948.

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https://ceog.imrpress.com/EN/10.31083/j.ceog4804149     OR     https://ceog.imrpress.com/EN/Y2021/V48/I4/942

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